Therapeutic Interventions Using Ursolic Acid for Cancer TreatmentRay Navin and Soo Mi Kim*
Department of Physiology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Republic of Korea
- *Corresponding Author:
- Soo Mi Kim
Department of Physiology, Institute for Medical Sciences
Chonbuk National University Medical School, Gungiro 20
Deokjin-Gu, Jeonju 561-180, Republic of Korea
E-mail: [email protected]
Received date: May 09, 2016; Accepted date: May 19, 2016; Published date: May 24, 2016
Citation: Navin R, Kim SM (2016) Therapeutic Interventions Using Ursolic Acid for Cancer Treatment. Med chem (Los Angeles) 6:339-344. doi:10.4172/2161-0444.1000367
Copyright: © 2016 Navin R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Current research has supported the potential of plant-derived natural compounds for the treatment and prevention of cancer and ursolic acid (UA) is one such compound. Unraveling the molecular mechanism of the protective effects of UA could establish a novel foundation to treat cancer. Studies have demonstrated that UA targets intracellular and extracellular molecules that are responsible for processes such as apoptosis, metastasis, autophagy, angiogenesis, oxidative stress, and inflammation. UA can reportedly be used as a potential drug when integrated with modern technological advancements to treat cancer and other diseases. In this review, the availability, chemical structures and properties, bioactivity, and the different molecular mechanisms of UA against cancer are compiled to understand the multiple aspects as well as the limitations of this potential treatment.