alexa Therapeutic use of Fisetin and Fisetin Loaded on Mesoporous Carbon Nanoparticle (MCN) in Thioglycollate-induced Peritonitis | OMICS International
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Therapeutic use of Fisetin and Fisetin Loaded on Mesoporous Carbon Nanoparticle (MCN) in Thioglycollate-induced Peritonitis

Shinjini Mitra1, Silpak Biswas1, Aryabaran Sinha2, Nikhil Ranjan Jana2 and Ena Ray Banerjee1*

1Department of Zoology, Immunology and Regenerative Medicine Research Laboratory, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India

2Centre for Advanced Materials, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India

*Corresponding Author:
Ena Ray Banerjee
Associate Professor, Department of Zoology
Immunology and Regenerative Medicine Research Laboratory
University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India
Tel: 9163739975
Fax: 91-33-24614849
E-mail: [email protected]

Received Date: October 13, 2015; Accepted Date: November 25, 2015; Published Date: December 05, 2015

Citation: Mitra S, Biswas S, Sinha A, Jana NR, Banerjee ER (2015) Therapeutic use of Fisetin and Fisetin Loaded on Mesoporous Carbon Nanoparticle (MCN) in Thioglycollate-induced Peritonitis. J Nanomed Nanotechnol 6:332. doi:10.4172/2157-7439.1000332

Copyright: © 2015 Mitra S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The pathophysiology of aseptic peritonitis involves inflammation of the serosal membrane that lines the abdominal cavity and the organs contained therein. The etiology of peritonitis is complicated and is involved in various processes, of which, the most important one is the inflammatory reaction. During the pathological process of peritonitis, NF-κB plays an activating role in the inflammatory reaction, which might be a potential therapeutic target in the therapy of certain inflammatory diseases. We studied the anti-inflammatory and pro-regenerative actions of Fisetin, a flavonol found in many plants, in a mouse model of thioglycollate-induced peritonitis, as well as the actions of fisetin administered with a nanoparticle such as mesoporous carbon nanoparticle (MCN). BALB/c mice were used in this study. Results: We found cell recruitment in the blood increased with the administration of thioglycollate (TG) after 24 h, 48 h, 72 h and 96 h, showing that it has induced inflammation. Cell recruitment was successfully inhibited by fisetin, and with MCN+fisetin. In the peritoneal fluid, total cell recruitment was increased, which was successfully inhibited with fisetin and MCN+fisetin treatment. TG treatment significantly reduced cell proliferation in the blood, PF and BM, within 24 h, till 96 h. Interestingly, cell proliferation increased with fisetin treatment, and with MCN+fisetin. The clonogenic potential of the tissues decreased significantly within 24 h, with administration of TG. Both fisetin treatment and MCN+fisetin treatment restored the clonogenic potential of the tissues. There was a decrease in Th2 cytokines with TG treatment, in blood after 48 h, and both fisetin and MCN+fisetin increased the cytokine content. Conclusion: In conclusion, we found that fisetin had a promising therapeutic effect on the peritonitis.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version