alexa Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Research Article

Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure

Guifang Zeng1#, Qiongshu Li1#, Hongfang Ju2#, Xin Zhou1, Jiaolian Zhu1, Xiaoping Zeng1, Yixin He1, Chan Li1, Jia Liu1, Chunfeng Wu1, Tenglong Yan1, Man Wu1, Jingyi Gan1, Wei Li3, Jiuwei Cui3, Xiang Hu1*, Ji-Fan Hu3,4* and Tao Li1*

1Shenzhen Beike Cell Engineering Research Institute, Nanshan, Shenzhen, P. R. China

2Obstetrics Department, Taizhou People’s Hospital, Taizhou, Jiangsu, P. R. China

3Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin, P. R. China

4Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA, USA

#Equal contribution to the project

*Corresponding Authors:
Jifan Hu
Stanford University Medical School, Palo Alto Veterans Institute for Research
Palo Alto, CA, USA
Tel: +1 650-493-5000 x63175
Fax: 1 650-849-1213
E-mail: [email protected]

Xiang Hu
Shenzhen Beike Cell Engineering Research Institute, Nanshan
Shenzhen, P. R. China
Tel: +86 755 86309298
Fax: +86 755 86309309
E-mail: [email protected]

Tao Li
Shenzhen Beike Cell Engineering Research Institute
Nanshan, Shenzhen, P.R. China
Tel: +86 755 86026162
Fax: +86 755 86026165
E-mail: [email protected]

Received date: November 09, 2015; Accepted date: November 24, 2015; Published date: November 26, 2015

Citation: Zeng G, Li Q, Ju H, Zhou X, Zhu J, et al. (2015) Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure. J Stem Cell Res Ther 5:316. doi:10.4172/2157-7633.1000316

Copyright: © 2015 Zeng G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Mesenchymal stem cells (MSCs) are powerful sources for cell therapy in regenerative medicine due to their capacity for self-renewal, multilineage differentiation, and immune modulation. Placenta-derived stem cells (PDSCs) have been recently suggested as alternative sources of stem cells. However, comparative studies to decide the most suitable cells for cell-based therapeutics are largely lacking. This study attempted to compare the potential of PDSCs in the treatment of mice with acute hepatic failure (ALF). We isolated four types of PDSCs, including the fetus-derived chorionic villi MSCs (CV-MSCs), Wharton’s jelly umbilical cord MSCs (WJ-MSCs) and amnion MSCs (AE-MSCs), and the maternally derived decidua basalis MSCs (DB-MSCs). We found that all PDSCs showed similar biological properties, including morphology, specific surface antigen, proliferation, and multipotent differentiation potential (osteogenesis, adipogenesis and chondrogenesis). In addition, they also exhibited similar therapeutic potential in rescuing acetaminophen-induced ALF in mice, regardless of their origins. However, the fetus-derived CV-MSCs and WJ-MSCs exhibited the highest proliferative potential and the best improvement of survival rate in mice with ALF. Taken together, our data suggest that PDSCs, particularly CV-MSCs and WJ-MSCs, may have greater potential to be banked for clinical use.

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