alexa Therapeutical Potential of Microvesicles in Cardiovascular Diseases | OMICS International | Abstract
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
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Editorial

Therapeutical Potential of Microvesicles in Cardiovascular Diseases

Yasukatsu Izumi*

Department of Pharmacology, Osaka City University Medical School, Osaka, Japan

*Corresponding Author:
Yasukatsu Izumi
Department of Pharmacology
Osaka City University Medical School
1-4-3 Asahi-machi, Abeno-ku
Osaka 545-8585, Japan
Tel: +81-6-6645-3731
Fax: +81-6-6646-1980
E-mail: [email protected] osaka-cu.ac.jp

Received date: May 10, 2012; Accepted date:May 14, 2012; Published date: May 16, 2012

Citation: Izumi Y (2012) Therapeutical Potential of Microvesicles in Cardiovascular Diseases. J Genet Syndr Gene Ther 3:e107. doi:10.4172/2157-7412.1000e107

Copyright: © 2012 Izumi Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

MicroRNAs (miRNAs) are small, highly conserved, non-coding RNA molecules that regulate hundreds of gene expression and thereby, affect global changes in the physiology of cells. Extracellular miRNAs are packaged with proteins or wrapped in microvesicles including microparticles, exosomes, and apoptotic bodies. These vesicles are potential candidates for therapeutical targets. Recent studies have indicated that microvesicles have the roles of deleterious information in blood vessel wall under pathological situations such as hypertension, myocardial infarction and metabolic syndrome, whose diseases are results of the endothelial dysfunction. However, the role of endothelial cells-derived microvesicles is unknown. Uncovering the difference and potential role of these microvesicles in endothelial cells is emerging

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