alexa Therapies for Chronic Hepatitis B: Review of Indications, Outcomes and New Tools for Tailoring Treatments to Patients | OMICS International | Abstract
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Therapies for Chronic Hepatitis B: Review of Indications, Outcomes and New Tools for Tailoring Treatments to Patients

Catherine M N Croagh*, Sally J Bell and Paul V Desmond

Department of Gastroenterology, St Vincent’s Hospital, Level 4, Daly Wing, 35 Victoria Parade, Fitzroy 3065, Australia

*Corresponding Author:
Catherine M N Croagh
Department of Gastroenterology
St Vincent’s Hospital, Level 4, Daly Wing
35 Victoria Parade, Fitzroy 3065, Australia
Tel: +61 3 9288 3580
Fax: +61 3 9288 3581
E-mail: [email protected]

Received Date: April 29, 2014; Accepted Date: May 27, 2014; Published Date: June 02, 2014

Citation: Croagh CMN, Bell SJ, Desmond PV (2014) Therapies for Chronic Hepatitis B: Review of Indications, Outcomes and New Tools for Tailoring Treatments to Patients. J Antivir Antiretrovir 6:068-074. doi: 10.4172/jaa.1000100

Copyright: © 2014 Croagh CMN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Chronic Hepatitis B is a major cause worldwide of liver cirrhosis, hepatocellular carcinoma and liver related
mortality. The ultimate goals of treatment are to reduce the risk of these complications and the endpoints used in
clinical practice are viral suppression, ALT normalisation and histological regression of fibrosis as well as HBeAg
seroconversion in patients who are HBeAg positive. The indications for treatment differ slightly in different regions
however may still be conceptualised in terms of the phase of chronic hepatitis B Treatment options include a finite
course of Peg IFN which has immunomodulatory as well as antiviral effects although its use may be limited by
troublesome side effects and low efficacy in some patients. Recent advances in the use of quantitative HBsAg
and HBeAg levels during Peg IFN treatment has provided some predictors of response and therefore the ability to
individualise treatment courses to a degree, avoiding unnecessary prolongation of treatment where it is likely to be
futile. The oral nucleoside/nucleotide analogues now available have high potency and very low rates of resistance
however must be continued indefinitely in HBeAg negative patients and most HBeAg positive patients. Lifelong
treatment raises issues of side effects such as renal and bone disease, compliance, and management during
pregnancy. Research aimed at novel targets in the HBV life cycle or host immune response is ongoing. The ultimate
goal of therapies for CHB remains HBsAg clearance which at present still occurs only in a minority of cases.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7