alexa Thermodynamic Studies of DNA-Cationic Components Interactions Using Titration Calorimetry
ISSN: 2157-7544

Journal of Thermodynamics & Catalysis
Open Access

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Review Article

Thermodynamic Studies of DNA-Cationic Components Interactions Using Titration Calorimetry

Shawn D Wettig1* and Amany O Kamel1,2
1School of Pharmacy and Waterloo Institute of Nanotechnology, University of Waterloo University Ave. W., Waterloo, Canada
2Department of Pharmaceutics and Industrial Pharmacy, School of Pharmacy, Ain Shams University, Cairo, Egypt
Corresponding Author : Shawn D Wettig
School of Pharmacy and Waterloo Institute of Nanotechnology
University of Waterloo University Ave, Canada
E-mail: [email protected]
Received May 30, 2013; Accepted June 17, 2013; Published June 19, 2013
Citation: Wettig SD, Kamel AO (2013) Thermodynamic Studies of DNA-Cationic Components Interactions Using Titration Calorimetry. J Thermodyn Catal 4: 121. doi:10.4172/2157-7544.1000121
Copyright: © 2013 Wettig SD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

DNA delivery to cells has gained much attention as a powerful approach in gene therapy for treatment of
inherited and acquired diseases. The transfection process depends on the nature of the binding interaction between DNA components of the non-viral delivery vector. The aim of this review is to explore the use of isothermal titration microcalorimetry (ITC) in the investigation of thermodynamic binding interactions between DNA and cationic components essential for DNA targeting to the cells. The review will focus on the interaction of DNA with block copolymers, surfactants and cationic lipids.

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