Thermo-Responsive Core-Shell Composite Nanoparticles Synthesized via One-Step Pickering Emulsion Polymerization for Controlled Drug Delivery
Sriya Sanyal, Huang-Chiao Huang, Kaushal Rege and Lenore L. Dai*
Chemical Engineering, Arizona State University, Tempe, AZ 85287, USA
- *Corresponding Author:
- Lenore L. Dai
School for Engineering of Matter
Transport and Energy
Arizona State University
Tempe, AZ 85287, USA
Tel: 480- 965-4112
E-mail: [email protected]
Received Date: November 20, 2011; Accepted Date: December 23, 2011; Published Date: December 26, 2011
Citation: Sanyal S, Huang H, Rege K, Dai LL (2011) Thermo-Responsive Core- Shell Composite Nanoparticles Synthesized via One-Step Pickering Emulsion Polymerization for Controlled Drug Delivery. J Nanomedic Nanotechnol 2:126. doi:10.4172/2157-7439.1000126
Copyright: © 2011 Sanyal S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elevated temperatures. The ability of the various nanoparticles for inducing death in human prostate cancer cells has been evaluated. Conclusion: The work has demonstrated the temperature sensitivity, controlled drug release properties of the synthesized core-shell nanoparticles, and their effectiveness for inducing death of human prostate cancer cells.