alexa Threatening Problem of Stenotrophomonas maltophilia Producing Extended-Spectrum Beta-Lactamases: Prevalence and Automated Antibiotic Susceptibility Pattern
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Research Article

Threatening Problem of Stenotrophomonas maltophilia Producing Extended-Spectrum Beta-Lactamases: Prevalence and Automated Antibiotic Susceptibility Pattern

Nada Abdel-Aziz1,2*, Mohamed-Mofeed Fawaz Morsy2, Sahar Saadallah Amin3, Kawthar I Mohammed3, Ahmed E Alharbi4 and Issam Alshami4

1Faculty of Medicine, Taibah University, KSA

2Faculty of Medicine, Sohag University, Egypt

3Faculty of Medicine, Ain Shams University, Egypt

4Faculty of Medicine, Taibah University, Saudi Arabia

*Corresponding Author:
Nada Abdelmohsen Mohamed Abdel-Aziz
Faculty of Medicine, Taibah University
KSA, Faculty of Medicine, Sohag University, Egypt
Tel: 00966503558083
E-mail: [email protected]

Received Date: February 21, 2013; Accepted Date: April 09, 2013; Published Date: April 12, 2013

Citation: Abdel-Aziz N, Morsy MMF, Amin SS, Mohammed KI, Alharbi AE, et al. (2013) Threatening Problem of Stenotrophomonas maltophilia Producing Extended-Spectrum Beta-Lactamases: Prevalence and Automated Antibiotic Susceptibility Pattern. Clin Microbial 2:108. doi:10.4172/2327-5073.1000108

Copyright: © 2013 Abdel-Aziz N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Stenotrophomonas maltophilia (S. maltophilia) is one of the most common emerging multi-drug resistant organisms. It is associated with difficult detection, treatment, and increased mortality particularly among immune compromised and debilitated individuals. Objectives: To determine the prevalence and antibiotic susceptibility pattern of S. maltophilia as emerging problem from different clinical isolates. Methods: A cross sectional study was conducted on 14000 cases. The isolates of Gram negative bacilli were identified based on conventional microbiological procedures. Extended spectrum beta lactamases (ESBLs) producing S. maltophilia identification and antibiotic susceptibility was further confirmed using automated BD Phoenix system where the panel of Gram negative antibiotics was tested. Results: Out of 14000 reviewed cases, 2100 were proved to be culture positive. Among Gram negative isolates, 1.5% was proved to be S. maltophilia. One hundred fourteen of Gram negative isolates were proved to be ESBL producers. More than half of ESBL isolates were E-coli. S. maltophilia represents (8.77%) of total Gram negative ESBL producers, while ESBL producing S. maltophilia represent (83.33%) among the total number of S. maltophilia isolates. Half number of S. maltophilia isolates was obtained from blood. About 83 % of S. maltophilia isolates showed resistance to all Gram negative Panels of antibiotics, while 100% of isolates were sensitive to Trimethoprimsulfamethoxazole (TMP – SXT). 16.67% of isolates showed sensitivity to ciprofloxacin (CIP), ceftazidime (CAZ). Conclusion: ESBL producing S. maltophilia is frequently resistant to a wide range of commonly used antimicrobials. Routine sensitivity reporting is required to detect these threatening, multidrug resistant organisms. Trimethoprim-sulfamethoxazole (TMP – SXT) is recommended as the agent of choice for the treatment of S. maltophilia infections. Alternatively, fluoroquinolones and ceftazidime (CAZ) may be used.

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