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Three Cases of Major Depression: Different Pharmacological Antidepressant Options | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Case Report

Three Cases of Major Depression: Different Pharmacological Antidepressant Options

Felix-Martin Werner1,2* and Rafael Covenas2

1Higher Vocational School of Elderly Care and Occupational Therapy, Euro Academy Pößneck, Pößneck, Thuringia, 07381, Germany

2Laboratory of Neuroanatomy of the Peptidergic Systems (Lab. 14), Institute of Neurosciences of Castilla y León (INCYL), University of Salamanca, Castilla-León, 37007-Salamanca, Spain

*Corresponding Author:
Werner FM
Medical Doctor, Dr. Med
Research Field: Neural Networks in Neurological and Psychiatric Diseases
University of Salamanca, Instituto de Neurociencias de Castilla y León (INCYL)
Laboratorio de Neuroanatomía de los Sistemas
Peptidérgicos (Lab. 14), c/ Pintor Fernando Gallego
1, 37007-Salamanca, Spain
Tel: +34/923/294400; extn. 1856
Fax: +34/923/29 45 49
E-mail: [email protected]

Received Date: June 01, 2017; Accepted Date: June 20, 2017; Published Date: June 28, 2017

Citation: Werner FM, Covenas R (2017) Three Cases of Major Depression: Different Pharmacological Antidepressant Options. J Cytol Histol 8: 457. doi: 10.4172/2157-7099.1000457

Copyright: © 2017 Werner FM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Three cases with different forms of major depression and different pharmacological antidepressant treatments are presented. In the first case report, citalopram, a selective serotonin reuptake inhibitor, improved transient depressive symptoms in a professionally busy man who recovers from the depressive symptoms and solves the social problems in his team. In the second case report showing a severe form of major depression and a suicide attempt, the tricyclic antidepressant drug doxepin failed to improve depressive symptoms. The selective serotonin and noradrenaline reuptake inhibitor venlafaxine partly improved depressive symptoms. Lithium carbonate, a prophylactic drug, which shows antidepressant and antimanic effects, treated depressive symptoms successfully. The cardiac and renal adverse effects were controlled. In the third case report, citalopram was used to treat the chronic form of major depression; however the adverse effects such as sedating and drive-reducing effects and the weight gain were disturbing for the patient. The administration of the selective dopamine and noradrenaline reuptake inhibitor bupropion ameliorated depressive symptoms and sleepiness, however caused hypertension and insomnia. Due to this changed medication, the patient succeeded in coping with a stressful life event, an anti-cancer therapy.