Thromboembolic Events among Patients with Sickle Cell Disease: Risk Factors and Prevalence in a Tertiary Hospital in Saudi ArabiaFarjah Hassan Al-Gahtani*
Division of Hematology/Oncology, Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia
- *Corresponding Author:
- Dr. Farjah Hassan Al-Gahtani, M.D
Associate Professor, MPH Division of Hematology/Oncology, Department of Medicine
King Khalid University Hospital, King Saud University, Riyadh, 11461, Kingdom of Saudi Arabia
E-mail: [email protected]
Received date: September 24, 2016; Accepted date: October 18, 2016; Published date: October 25, 2016
Citation: Al-Gahtani FH (2016) Thromboembolic Events among Patients with Sickle Cell Disease: Risk Factors and Prevalence in a Tertiary Hospital in Saudi Arabia. J Hematol Thrombo Dis 4:254. doi:10.4172/2329-8790.1000254
Copyright: © 2016 Al-Gahtani FH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Sickle Cell Disease (SCD) can be complicated by thromboembolic disease. However, up-to-date there is no clarity on the risk factors associated with this complication. Here we report the prevalence of Thromboembolic Disease (TED) among SCD patients and find out factors associated with the development of these thromboembolic events in SCD. Methods: Retrospective review of medical records of 477 patients diagnosed with SCD at King Khalid University Hospital, Riyadh, Saudi Arabia seen between 1982 and 2008. Review included demographic data, diagnosis, comorbidities, type of SCD, laboratory and coagulation profiles, treatment, mortality, cause of death and adverse events including stroke, deep vein thrombosis, and infarction. Results: TED was documented in 8.4% of our patients. Patients who developed TED had higher prevalence of trauma, transient immobility and chest infection and higher serum ferritin levels. The prevalence of TED was significantly associated with history of trauma, transient immobility, D-dimer level, serum ferritin level, presence of chest infection and HS.