alexa Thrombo-Embolic Events in Cancer Patients with Impaired Renal Function
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Review Article

Thrombo-Embolic Events in Cancer Patients with Impaired Renal Function

Elalamy I*, Canon JL, Bols A, Lybaert W, Duck L, Jochmans K, Bosquée L, Peeters M, Awada AH, Clement P, Holbrechts S, Baurain JF,
Mebis J and Nortier J

Department of Thrombosis Center, CHU Tenon, Rue de la Chine 4, 75020 Paris, France

*Corresponding Author:
Elalamy I
Professor of Hematology and Director of Hematology
Department of Thrombosis Center, CHU Tenon
Paris, Rue de la Chine 4, 75020 Paris, France
Tel: +33 (0)1 56 01 70 00
E-mail: [email protected]

Received date: January 23, 2014; Accepted date: March 17, 2014; Published date: March 23, 2014

Citation: Elalamy I, Canon JL, Bols A, Lybaert W, Duck L, et al. (2014) Thrombo-Embolic Events in Cancer Patients with Impaired Renal Function. J Blood Disord Transfus 5:202. doi: 10.4172/2155-9864.1000202

Copyright: © 2014 Elalamy I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Venous Thromboembolism (VTE) is a frequent cause of mortality and morbidity in patients with malignancy. Thrombosis is one of the leading causes of death in patients with malignancy after cancer itself. As such, prompt recognition and treatment of VTE are required in order to reduce the risk of VTE-related mortality. This report reviews the interrelationship between cancer, renal insufficiency and VTE. The working group behind this review article concludes that Low Molecular Weight Heparins (LMWHs) decrease the risk of recurrent venous thrombosis in cancer patients without increasing major bleeding complications. LMWHs are therefore recommended as first line antithrombotic treatment in cancer patients with a clear clinical benefit. In patients with renal dysfunction, who are at both increased risk of bleeding and of thrombotic complications, preference should be given to unfractionated heparin or a LMWH with a mean molecular weight such as tinzaparin, having less risk of plasma accumulation and offering the possibility to maintain full therapeutic dose.

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