alexa Thrombotic Microangiopathy and Low ADAMTS 13: Case Report and Review of the Literature | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
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Case Report

Thrombotic Microangiopathy and Low ADAMTS 13: Case Report and Review of the Literature

Zakaria Almuwaqqat*, Saad Ali, Abduljalil Elfasi, Harvey Freidman and Afsin Oktay

Department of Internal Medicine, St.Francis Hospital, USA

*Corresponding Author:
Zakaria Almuwaqqat
Internal Medicine Resident, Presence St.Francis Hospital
Internal Medicine, 735 Chicago Ave, Apt 439
Evanston, IL 60202, USA
Tel: 2038247207
E-mail: [email protected]

Received Date: July 11, 2015 Accepted Date: September 01, 2015 Published Date: September 03, 2015

Citation: Almuwaqqat A, Ali S, Elfasi A, Freidman H, Oktay A (2015) Thrombotic Microangiopathy and Low ADAMTS 13: Case Report and Review of the Literature. J Cytol Histol 6:359. doi:10.4172/2157-7099.1000359

Copyright: © 2015 Almuwaqqat Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Thrombotic Microangiopathy (TMA) is a multi-organ dysfunction syndrome characterized by microvascular thrombosis, thrombocytopenia and hemolytic anemia with diverse etiologies ranging from primary Thrombotic thrombocytopenic purura (TTP) and Hemolytic uremic syndrome (HUS) to secondary phenomena to medications, severe uncontrolled hypertension and autoimmune disorders i.e Scleroderma renal crises, catastrophic antiphospholipid syndrome and pre-eclampsia, prompt diagnosis, identification of potential etiologies and treatment are essential steps for reducing morbidity and mortality.
Case Report: We describe a case of a 34-year-old man who presented with features of advanced renal impairment, severe uncontrolled hypertension and thrombotic microangiopathy, overall clinical picture was most consistent with malignant hypertension and hypertensive nephrosclerosis secondary to long standing uncontrolled hypertension, however a serum test ordered measuring the activity of ADAMTS 13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) resulted one week later was consistent with reduced enzyme activity, challenging the first diagnosis.
Conclusions: Clinical correlation and high index of suspicion are essential in the diagnosis and management of thrombotic microangiopathy, The reduction in ADAMTS -13 activity or antigen level has been thought to be a primary cause of thrombotic microangiopathies I.e TTP and HUS, however recent studies have shown a negative correlation between ADAMTS-13 activity and elevated blood pressure (BP) in malignant hypertension.

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