Thyroid Carcinoma (Tc) in Nodular Goitre
|Nikhil Nanjappa BA1*, Alok Mohanty1, Tirou Aroul T1, Robinson Smile S1 and Dhananjay Kotasthane2|
|1Department of Surgery, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India|
|2Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India|
|Corresponding Author :||Nikhil Nanjappa BA
Department of Surgery
Mahatma Gandhi Medical College & Research Institute
E-mail: [email protected]
|Received May 28, 2012; Accepted July 25, 2012; Published July 27, 2012|
|Citation: Nikhil Nanjappa BA, Alok Mohanty, Tirou Aroul T, Robinson Smile S, Dhananjay Kotasthane (2012) Thyroid Carcinoma (Tc) in Nodular Goitre. Thyroid Disorders Ther 1:115. doi:10.4172/2167-7948.1000115|
|Copyright: © 2012 Nikhil Nanjappa BA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Objective: To study the incidence and pathology of thyroid malignancy in patients operated for presumably benign nodular thyroid disease (multi nodular goitre (MNG) & solitary thyroid nodule (STN)).
Methods: A total of 175 patients who underwent surgery for presumably benign nodular thyroid disease between January 2004 and March 2012 were studied, prospectively. These patients underwent hemi, subtotal, total thyroidectomy.
Results: 37 of the 175 patients (21%) had malignancy on final histopathological examination. The mean age of patients with benign disease was 46.4 years and that with malignancies was 50.6 years. Mean size of nodules was 4.28 +/- 1.48 cm in the benign group and 4.21 +/- 1.48 cm in the malignant group. All those with MNG, 14/14 (100%) were papillary carcinoma and those with STN, 22/23 (95.7%) were papillary carcinoma. Among the papillary carcinomas, follicular variant was 15 and the micropapillary variant was 3.
Conclusions: The incidence of malignancy in nodular goiter is higher than what is usually reported. There was no significant difference in incidence of malignancy between MNG and STN (P value: 0.262). Papillary carcinoma was significantly higher in nodular goiter (97.3%). Papillary carcinoma was found in all patients who presented with MNG and all but one who presented with STN. Follicular variant of papillary carcinoma was more common than the micropapillary variant (40.5% and 8.1% respectively).