alexa Thyroxine: A Putative Neuroprotectant in Diabetes Induc
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Thyroxine: A Putative Neuroprotectant in Diabetes Induced Peripheral Neuropathy in Rats

Hariprasad MG1*, Rema Razdan1, Yasha TC2 and Tripathy Amrutanand S3

1Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore-560027, Karnataka, India

2Department of Neuropathology, NIMHANS, Bangalore, Karnataka, India

3Department of Pharmacognosy, Al-Ameen College of Pharmacy, Bangalore-560027, Karnataka, India

*Corresponding Author:
Hariprasad MG
Department of Pharmacology, Al-Ameen College of Pharmacy
Hosur Road, Near Lalbagh Main Gate
Bangalore-560027, Karnataka, India
Tel: 080-22234619, +91-9845117850
Fax: 08022225834
E-mail: hariprasadmg2004@ yahoo.com

Received date: July 30, 2015; Accepted date: August 22, 2015; Published date: August 26, 2015

Citation: Hariprasad MG, Razdan R, Yasha TC, Amrutanand ST (2015) Thyroxine: A Putative Neuroprotectant in Diabetes Induced Peripheral Neuropathy in Rats. J Diabetes Metab 6:595. doi:10.4172/2155-6156.1000595

Copyright: © 2015 Hariprasad MG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objectives: The treatment options for diabetic peripheral neuropathy (DPN) currently include anti-depressants, anti-convulsants and opioid analgesics. These agents are modestly effective for symptomatic relief, but they do not affect the underlying pathology nor do they slow progression of the disease. Therefore, effective treatment for diabetes induced neuropathy would be a major advantage for patients. It is well established. TH plays an important role in regulating the development and regeneration of the nervous system and local administration of triiodothyronine (T3) at the level of transected rat sciatic nerve increased the number and diameter of regenerated axons and SCG10 protein levels about two-fold in the different segments of transected nerve during the regeneration period. Thyroxine(T4) has shown the range of biological actions and is important in both development and maturation. The etiology of diabetic neuropathy revolves around, AGE formation, lipid peroxidation, oxidative stress etc. All these have been reported to stimulate inflammatory processes, which lead to DPN. Progression in DPN can cause functional and behavioral deficits. Therefore, the present study was undertaken to evaluate the protective effect of thyroxine in diabetes induced peripheral neuropathy in rats. Methods: Experimental diabetes in rats was induced by single intraperitoneal (i.p.) injection of Streptozotocin(SIGMA-ALDRICH, USA) at a dose of 55 mg/kg i.p. freshly dissolved in 100 mM sodium citrate buffer, pH 4.5. The degree of protection was determined by measuring behavioural parameters like motor in-coordination, thermal and cold hyperalgesia, grip strength, electrophysiological properties of sciatic nerve like nerve conduction velocity, and histopathological studies. Results: DPN was evidenced in diabetic control rats and ameliorated with administration of Thyroxine (T4) (1mg/kg, s.c.) thrice a week for 5 weeks by augmenting all the above parameters. Conclusions: T4 exhibited neuroprotective activity, which would be attributed to its activity as neurotrophic effect.

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