alexa Tiapride Associated Toxic Epidermal Necrolysis in an HIV-Infected Patient | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Tiapride Associated Toxic Epidermal Necrolysis in an HIV-Infected Patient

Paulo Andrade1*, Nuno Rocha Pereira1, Cândida Abreu1, Paula Egipto3, Daniel Moura2 and António Sarmento1
1Department of Infectious Diseases, Hospital de São João, Porto, Portugal
2Burn Unit, Hospital de São João, Porto, Portugal
3Department of Pharmacology, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Corresponding Author : Paulo Andrade
Department of Infectious Diseases
Hospital de São João, Porto, Portugal
Tel: +351967247061
E-mail: [email protected]
Received November 20, 2013; Accepted December 16, 2013; Published December 18, 2013
Citation: Andrade P, Pereira NR, Abreu C, Egipto P, Moura D, et al. (2013) Tiapride Associated Toxic Epidermal Necrolysis in an HIV-Infected Patient. J Clin Case Rep 3:323. doi:10.4172/2165-7920.1000323
Copyright: © 2013 Andrade P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Toxic epidermal necrolysis is a rare but severe and often fatal adverse cutaneous drug reaction. Early diagnosis and prompt discontinuation of the culprit drug is of the utmost importance, making drug causality assessment the mainstay when managing this condition. We present the first reported case of toxic epidermal necrolysis induced by tiapride, in a 43 year-old male Caucasian with a history of liver cirrhosis and HIV infection. This case report should raise awareness on the medical community to a potentially fatal reaction to a frequently prescribed drug in alcoholic patients. It also underlines the importance of further research regarding HIV infection, immune deregulation and adverse cutaneous drug reactions.

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