alexa Tibial Agenesis and Gollop-Wolfgang Complex in Three Siblings Born to an Epileptic Woman Treated with Carbamazepine: Teratogenicity | OMICS International | Abstract
ISSN: 2161-1041

Hereditary Genetics: Current Research
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Case Report

Tibial Agenesis and Gollop-Wolfgang Complex in Three Siblings Born to an Epileptic Woman Treated with Carbamazepine: Teratogenicity

Nasir Muzaffar*

Department of Orthopaedics, Hospital for Bone and Joint Surgery, Srinagar, Kashmir, India

*Corresponding Author:
Nasir Muzaffar
Bone and Joint Surgery Hospital, Barzalla
Srinagar, Kashmir, J&K, India; Pin-190005
Tel: 91-0194-2430155/2430149, 919858812593
Fax: 91-0194-2433730
E-mail: [email protected]

Received Date: September 04, 2013; Accepted Date: September 05, 2013; Published Date: September 10, 2013

Citation: Muzaffar N (2013) Tibial Agenesis and Gollop-Wolfgang Complex in Three Siblings Born to an Epileptic Woman Treated with Carbamazepine: Teratogenicity? Genetics 2:118. doi: 10.4172/2161-1041.1000118

Copyright: © 2013 Muzaffar N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The term “limb deficiency” incorporates absence and/or size reduction of any of the 120 human limb bones, with around 205 identified nosologic entities. Of these, the Gollop- Wolfgang Complex (GWC) is a rare abnormality comprising absence of tibia and ipsilateral forked femur with ectrodactyly. There is scarcity of literature implicating antiepileptic drugs in the etiology of GWC but the teratogenecity of antiepileptics especially valproate is well documented. The management of epilepsy during pregnancy requires a balance between control, the risks involved in uncontrolled seizures and the teratogenecity of antiepileptic drugs. This study presents three siblings with GWC and tibial agenesis whose epileptic mother had been on treatment with carbamazepine for 10 years. To the author’s knowledge, this is the first time that carbamazepine has been implicated in causation of GWC/tibial agenesis

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