Reach Us +447482877761
Tick Longicin Implicated in the Arthropod Transmission of <em>Toxoplasma Gondii</em> | OMICS International | Abstract
ISSN: 2157-7579

Journal of Veterinary Science & Technology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Tick Longicin Implicated in the Arthropod Transmission of Toxoplasma Gondii

Tetsuya Tanaka1, Hiroki Maeda1, Remil Linggatong Galay1, Damdinsuren Boldbattar1, Rika Umemiya-Shirafuji1, Hiroshi Suzuki2, Xuenan Xuan2, Naotoshi Tsuji3 and Kozo Fujisaki1*

1Laboratory of Emerging Infectious Diseases, Department of Frontier Veterinary Science, Faculty of Agriculture, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan

2National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan

3Laboratory of Parasitic Diseases, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki 305-0856, Japan

*Corresponding Author:
Dr. Prof. Kozo Fujisaki
Laboratory of Emerging Infectious Diseases
Joint Faculty of Veterinary Medicine
Kagoshima University, 1-21-24 Korimoto
Kagoshima 890-0065, Japan
Tel: +81- 99-285-3569
Fax: +81-99-285-3569
E-mail: [email protected]

Received date: February 15, 2012; Accepted date: March 20, 2012; Published date: March 26, 2012

Citation: Tanaka T, Maeda H, Galay RL, Boldbattar D, Umemiya-Shirafuji R, et al. (2012) Tick Longicin Implicated in the Arthropod Transmission of Toxoplasma gondii. J Veterinar Sci Technol 3:112. doi:10.4172/2157-7579.1000112

Copyright: © 2012 Tanaka T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Antimicrobial peptides are major components of host innate immunity, a well-conserved evolutionarily ancient defensive mechanism. Infectious disease-bearing vector ticks are thought to have evolved to produce specific defense peptides implicated in controlling the infection and transmission of various pathogens. Longicin, a defensin peptide identified from the hard tick, Haemaphysalis longicornis , is known to have a significant deadly effect against both Gram-negative and Gram-positive bacteria and other microorganisms. In this study, female H. longicornis ticks were experimentally injected with Toxoplasma gondii tachyzoite parasites, and the transcription profiles of longicin in ticks demonstrating the amplification of T. gondii B-1 gene fragments were examined to determine whether and how ticks may respond immunologically in controlling T. gondii infections. As a result, 10 days after parasite injection, ticks indicated the upregulation of the longicin gene, consistently with the presence of T. gondii . The effects of recombinant longicin on the morphology of T. gondii tachyzoites were also examined in vitro . Tachyzoite parasites incubated with recombinant longicin induced pathological changes in cell morphology followed by a marked reduction in the number of parasites. These findings suggested that recombinant longicin could impair parasite membranes, leading to the destruction of Toxoplasma parasites.


Recommended Conferences

15th International Veterinary Congress

Paris, France

Asia Pacific Veterinary Congress

Singapore, Singapore

8th International Conference on Parasitology & Microbes

Singapore, Singapore
Share This Page