alexa Time to Recurrence of any Opportunistic Infection after Treatment of it among People Living with HIV Infection in Debre Markos, Northwest Ethiopia: Retrospective Cohort Study
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Time to Recurrence of any Opportunistic Infection after Treatment of it among People Living with HIV Infection in Debre Markos, Northwest Ethiopia: Retrospective Cohort Study

Habtamu Mellie1, Getnet Mitike2 and Amanuel Alemu Abajobir1*

1Debre Markos University, Department of Public Health, Debre Markos, Ethiopia

2Addis Ababa Universities, School of Public Health, Addis Ababa, Ethiopia

*Corresponding Author:
Amanuel Alemu Abajobir
Debre Markos University
Department of Public Health
Debre Markos, Ethiopia
E-mail: [email protected]; [email protected]

Received Date: June 17, 2013; Accepted Date: July 25, 2013; Published Date: July 31, 2013

Citation: Mellie H, Mitike G, Abajobir AA (2013) Time to Recurrence of any Opportunistic Infection after Treatment of it among People Living with HIV Infection in Debre Markos, Northwest Ethiopia: Retrospective Cohort Study. J AIDS Clin Res 4:226. doi:10.4172/2155-6113.1000226

Copyright: © 2013 Mellie H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Antiretroviral therapy improves time to death of people living with HIV; however, little is known about its effect on improving time of recurrence of opportunistic infections after treatment of any preceding infection. Hence, this study was aimed at assessing time to recurrence of any opportunistic infection after treatment of any preceding opportunistic infection, its magnitude and associated factors.

Methods: Retrospective cohort study was used and the required sample size was 536. Study participants were selected randomly from the list of adult people living with HIV attending the public health facilities for ART. Univariate analysis was used to describe patients’ baseline and follow up characteristics. Kaplan-meier survival and log rank test were used to estimate survival and compare survival curves respectively. Cox proportional-hazard regression model was used to calculate hazard rate and to determine independent predictors of time to recurrence.

Results: During a median of 43 person weeks follow up, opportunistic infections recurred in 75.7% the participants and the proportion was not significantly different (p=0.614) in pre-ART and ART people living with HIV. The incidence rate of any opportunistic infection recurrence was 1.31 per 100 person weeks which differs by ART exposure status which was 1.57 and 1.13 per 100 person weeks in pre-ART and ART PLHIV respectively. The median time of survival was 57 weeks; however, it was different in pre-ART and ART PLHIV that was 52 and 64 weeks respectively. Marital status, occupational status, follow up CD4 count, base line hemoglobin value, ART exposure, base line ART adherence, base line and follow up prophylaxis exposure and adherence were predictors of survival.

Conclusion: The incidence rate of any opportunistic infection recurrence was 1.31 per 100 person weeks. Attention should be given for widowed, ART/prophylaxis non-adhering patients while continuing HIV care for all people living with the virus.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version