alexa Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia
ISSN: 2329-910X

Clinical Research on Foot & Ankle
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Case Report

Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia

Igor Frangež1*, Tea Nizič-Kos1, Matej Cimerman1 and Dragica Maja Smrke2
1University Medical center Ljubljana, Department of traumatology, Zaloška cesta 2, Ljubljana, Slovenia
2University Medical center Ljubljana, Department of surgical infections, Zaloška cesta 2, Ljubljana, Slovenia
Corresponding Author : Dr. Igor Frangež
University Medical center Ljubljana
Department of traumatology, Zaloška cesta 2
Ljubljana, Slovenia
Tel: 0038641682112; E-mail: [email protected]
Received October 25, 2014; Accepted October 30, 2014; Published October 31, 2014
Citation: Frangež I, Kos TN, Cimerman M, Smrke DM (2014) Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia. Clin Res Foot Ankle 2:157. doi:10.4172/2329-910X.1000157
Copyright: © 2014 Frangez I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Chronic osteomyelitis is a serious and difficult complication in open fractures, occurring in about 20% of cases. Treatment approach must be multidisciplinary with surgical basis. At the end of the classical eradication of the infection, there is often a large bone defect. Guided tissue regeneration (GTR) with allogeneic platelet gel, autologous cancellous bone graft and resorptive collagen membrane is one of the possibilities how to bridge bone defect. Patients: 26 year old male patient, suffered from chronic osteomyelitis. The therapy for osteomyelitis was started and after two months osteomyelitis was healed, soft tissue defect was grafted with surralis flap. GTR with allogeneic platelet gel and autologous cancellous bone graft and resorptive collagen membrane was performed to fill the defect. Results: The essential idea of this therapy was to combine the healing capacities of platelet-derived growth factors and osteogenic stem cells and the modeling capacity of the platelet gel. After 4 months of GTR therapy the graft was incorporated, the bone defect was fully bridged and full weight-bearing capacity was achieved. Using resorptive collagen membrane, healing capacities of tissue increased. Conclusions: The aim of our treatment approach, with GTR by allogeneic platelet gel, autologous and bone graft combined with collagen resorptive membrane can improve and shorten the treatment outcome.

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