alexa TLC- Densitometric Method for Determination of some Cholesterol Lowering Drugs in Different Combinations
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
Open Access

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Research Article

TLC- Densitometric Method for Determination of some Cholesterol Lowering Drugs in Different Combinations

Nada S Abdelwahab1*, Badr A EL-Zeiny2 and Salwa I Tohamy1

1Department of Analytical Chemistry, Faculty of pharmacy, Beni-suif University, Egypt

2Department of Analytical Chemistry, Faculty of pharmacy, Cairo University, Egypt

*Corresponding Author:
Nada S Abdelwahab
Department of Analytical Chemistry
Faculty of pharmacy
Beni-suif University, Egypt
Tel: +201117236884
Fax: +208212317950
E-mail: [email protected]

Received date: April 14, 2012; Accepted date: May 21, 2012; Published date: May 23, 2012

Citation: Abdelwahab NS, EL-Zeiny BA, Tohamy SI (2012) TLC- Densitometric Method for Determination of some Cholesterol Lowering Drugs in Different Combinations. J Chromat Separation Techniq 3:126. doi:10.4172/2157-7064.1000126

Copyright: © 2012 Abdelwahab NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Sensitive, selective, precise and economic TLC-Densitometric method has been developed for determination of two binary mixtures containing the antihyperlipidemic Ezetimibe (EZ) in its combination with Atorvastatin calcium (AT) [mixture I] and with Simvastatin (SIM) [mixture II].In the developed TLC-Densitometric method EZ, AT and SIM were quantitatively separated on 60F254 silica gel plates using ethyl acetate: hexane: glacial acetic acid (5.5:4.5:0.1 by volume) as a developing system with UV detection at 254 nm. Factors affecting the chromatographic separation have been studied, moreover the method has been validated as per ICH guidelines and it has been successfully applied for determination of the studied drugs in their different dosage forms without interference from excepients. Results obtained by the developed TLCDensitometric method were statistically compared with those obtained by the reported spectrophotometric method and no significant difference was found between them.

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