TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer ProgressionJason St. John#, Katelyn Powell#, M. Katie Conley-LaComb and Sreenivasa R. Chinni*
Departments of Urology and Pathology, Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
- *Corresponding Author:
- Sreenivasa R. Chinni, Ph.D
Departments of Urology and Pathology
Wayne State University School of Medicine
9245 Scott Hall, 540 E. Canfield Avenue
Detroit, MI 48201, USA
E-mail: [email protected]
Received date: March 21, 2012; Accepted date: April 24, 2012; Published date: April 26, 2012
Citation: John JS, Powell K, Conley-LaComb MK, Chinni SR (2012) TMPRSS2- ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer Progression. J Cancer Sci Ther 4: 094- 101. doi:10.4172/1948-5956.1000119
Copyright: © 2012 John JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
TMPRSS2-Ets gene fusions were identified in prostate cancers where the promoter of transmembrane protease, serine 2 (TMPRSS2) fused with coding sequence of the erythroblastosis virus E26 (Ets) gene family members. TMPRSS2 is an androgen responsive transmembrane serine protease. Ets family members are oncogenic transcription factors that contain a highly conserved Ets DNA binding domain and an N-terminal regulatory domain.
Fusion of these gene results in androgen dependent transcription of Ets factor in prostate tumor cells. The ERG is the most common fusion partner with TMPRSS2 promoter in prostate cancer patients. The high prevalence of these gene fusions, in particular TMPRSS2-ERG, makes them attractive as potential diagnostic and prognostic indicators, as well as making them a potential target for tailored therapies.
This review focuses on the clinical and biological significance of TMPRSS2-ERG fusions and their role in PC development and progression.