alexa To Investigate the Impact of Laparoscopic Resection of Colorectal Carcinoma on the Peritoneal Metastases of Cancer | OMICS International | Abstract
[Jurnalul de Chirurgie]
ISSN: 1584-9341

Journal of Surgery
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Case Report

To Investigate the Impact of Laparoscopic Resection of Colorectal Carcinoma on the Peritoneal Metastases of Cancer

Xin Wang*, Anren Sun, Linkang Xiao and Rong Yang

Department of General Surgery, People’s Hospital of Chongqing City, China

*Corresponding Author:
Xin Wang
Department of General Surgery
People’s Hospital of Chongqing City
China
Tel: 13436134987
E-mail: [email protected]

Received Date: April 27, 2016; Accepted Date: June 18, 2016; Published Date: June 25, 2016

Citation: Wang X, Sun A, Xiao L, Yang R. To Investigate the Impact of Laparoscopic Resection of Colorectal Carcinoma on the Peritoneal Metastases of Cancer. Journal of Surgery [Jurnalul de chirurgie]. 2016; 12(2): 79-81 DOI: 10.7438/1584-9341-12-2-8

Copyright: © 2016 Wang X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To explore the effect of laparoscopy on cancer cells and the expressions of adhesion molecules (ICAM‐1, CD44v6 & integrin β1) in peritoneal tissue and abdominal rinse in patients with colorectal carcinoma (CC). Methods: A total of 65 CC cases undergoing radical resection at our hospital were analyzed. They were divided into two groups of LAP (laparoscopy, n=35) and OP (open surgery, n=30). Peritoneal tissues were collected at incision and beyond .Also abdominal rinse was collected before tumor resection and abdomen closure. The expressions of adhesion molecules (ICAM‐1 ,CD44v6 & integrin beta 1) in peritoneal and abdominal cavities of two groups were detected by immunohistochemistry and double‐antibody sandwich ABC‐ELISA. And cancer cells in abdominal rinse were detected by peritoneal lavage cytology (PLC) for comparing two surgical methods. Results: In LAP group, PLC was positive in 3 cases (8.6%) before tumor resection and 8 cases (22.9%) before abdominal closure. In OP group, PLC was positive in 4 cases (13.3%) before tumor resection and 8 cases (26.7% ) before abdominal closure. No inter‐group difference existed in PLC (P>0.05). The expressions of CD44v6, ICAM‐1 and integrin beta 1 in abdominal cavity (before tumor resection & abdomen closure) were compared for LAP and OP groups. And there was no statistically significant difference ( P>0 05). The expressions of CD44v6 ,ICAM‐1 and integrin beta 1 in peritoneal tissues (at incision and beyond) were compared between LAP and OP groups .And there was no statistically significant difference (P>0.05) . Conclusion: Compared with CC patients undergoing traditional open surgery, the risk of exfoliated cancer cells in abdominal cavity shows no increase. And there is no impact `upon the expressions of adhesion molecules.

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