To Investigate the Impact of Laparoscopic Resection of Colorectal Carcinoma on the Peritoneal Metastases of Cancer
Xin Wang*, Anren Sun, Linkang Xiao and Rong Yang
Department of General Surgery, People’s Hospital of Chongqing City, China
- *Corresponding Author:
- Xin Wang
Department of General Surgery
Hospital of Chongqing City
E-mail: [email protected]
Received Date: April 27, 2016; Accepted Date: June 18, 2016; Published Date: June 25, 2016
Citation: Wang X, Sun A, Xiao L, Yang R. To Investigate the Impact of
Laparoscopic Resection of Colorectal Carcinoma on the Peritoneal Metastases
of Cancer. Journal of Surgery [Jurnalul de chirurgie]. 2016; 12(2): 79-81 DOI:
Copyright: © 2016 Wang X, et al. This is an open-access article distributed under
the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and
source are credited.
Objective: To explore the effect of laparoscopy on cancer cells and the expressions of adhesion molecules (ICAMÃ¢ÂÂ1, CD44v6 & integrin β1) in peritoneal tissue and abdominal rinse in patients with colorectal carcinoma (CC).
Methods: A total of 65 CC cases undergoing radical resection at our hospital were analyzed. They were divided into two groups of LAP (laparoscopy, n=35) and OP (open surgery, n=30). Peritoneal tissues were collected at incision and beyond .Also abdominal rinse was collected before tumor resection and abdomen closure. The expressions of adhesion molecules (ICAMÃ¢ÂÂ1 ,CD44v6 & integrin beta 1) in peritoneal and abdominal cavities of two groups were detected by immunohistochemistry and doubleÃ¢ÂÂantibody sandwich ABCÃ¢ÂÂELISA. And cancer cells in abdominal rinse were detected by peritoneal lavage cytology (PLC) for comparing two surgical methods.
Results: In LAP group, PLC was positive in 3 cases (8.6%) before tumor resection and 8 cases (22.9%) before abdominal closure. In OP group, PLC was positive in 4 cases (13.3%) before tumor resection and 8 cases (26.7% ) before abdominal closure. No interÃ¢ÂÂgroup difference existed in PLC (P>0.05). The expressions of CD44v6, ICAMÃ¢ÂÂ1 and integrin beta 1 in abdominal cavity (before tumor resection & abdomen closure) were compared for LAP and OP groups. And there was no statistically significant difference ( P>0 05). The expressions of CD44v6 ,ICAMÃ¢ÂÂ1 and integrin beta 1 in peritoneal tissues (at incision and beyond) were compared between LAP and OP groups .And there was no statistically significant difference (P>0.05) .
Conclusion: Compared with CC patients undergoing traditional open surgery, the risk of exfoliated cancer cells in abdominal cavity shows no increase. And there is no impact `upon the expressions of adhesion molecules.