alexa Toll Like Receptors Play a Role in General Immunity, Ey
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Toll Like Receptors Play a Role in General Immunity, Eye Infection and Inflammation: Tlrs for Nanodelivery

Jagat R. Kanwar1*, Shu-Feng Zhou2, Sneha Gurudevan1, Colin J. Barrow1 and Rupinder K. Kanwar1
1Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (LIMBR), Centre for Biotechnology and Interdisciplinary Biosciences (BioDeakin), Institute for Technology and Research Innovation (ITRI), Geelong Technology Precinct (GTP), Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL
Corresponding Author : Dr. Jagat R. Kanwar
Associate Professor of Immunology & Cell Biology
Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (LIMBR)
Centre for Biotechnology and Interdisciplinary Biosciences (BioDeakin)
Institute for Technology and Research Innovation (ITRI)
Geelong Technology Precinct (GTP), Deakin University, Pigdons Road
Waurn Ponds, Geelong, Victoria 3217, Australia
Tel: 0061-3 -5227 1148
Fax: 0061-3-5227 3402
E-mail: [email protected]
Received June 06, 2011; Accepted September 03, 2011; Published September 06, 2011
Citation: Kanwar JR, Zhou SF, Gurudevan S, Barrow CJ, Kanwar RK (2011) Toll Like Receptors Play a Role in General Immunity, Eye Infection and Inflammation: Tlrs for Nanodelivery. J Clin Cell Immunol 2:114. doi:10.4172/2155-9899.1000114
Copyright: © 2011 Kanwar JR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Dendritic cells [DCs] are potent antigen presenting cells [APC], which plays a vital role in immune system by detecting and capturing pathogens in the body. DCs perform a pivotal role in induction of T cell response. Regulation of immune response can be achieved by specific antigen [Ag] delivery to DCs. A delivery system that can efficiently target and present Ags to DCs for the purpose of anti-tumour activity is currently a topic of significant research interest. DCs are receiving attention due to their key role in anti cancer host response and due to their adjuvanic property in tumour vaccines. Role of toll like receptors [TLR] in innate immune system and their part in eventual stimulation of adaptive immunity is exploited to develop vaccines. TLR agonists in conjugation with vaccines are shown to increase therapeutic efficacy in some cases. TLRs also play a vital role in protecting the cornea from invading pathogens. Due to adverse effects in the treatment of ocular inflammations, cancer and in viral infections, an alternate approach such as the use of TLRs will solve the inquisitive question regarding side effects. The intended delivery is attained by the use of nanoparticles which in turn leads to prolonged half-life in the body. Co-delivery of Ags, TLRs and immunomodulators using nanoparticles has been demonstrated to elicit potent cellular immune responses and are currently under development of clinically applicable immunisations and vaccines.

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