alexa Toll-Like Receptor 11: Role in Post-Transplantation Ren
ISSN: 2168-9431

Single Cell Biology
Open Access

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Short Communication

Toll-Like Receptor 11: Role in Post-Transplantation Renal Infections

Indra Mani* and Kavita Vasdev

Department of Microbiology, Gargi College, University of Delhi, Siri Fort Road, New Delhi, India

*Corresponding Author:
Indra Mani
Department of Microbiology, Gargi College
University of Delhi, Siri Fort Road
New Delhi, India
Tel: 91-9811873144
E-mail: [email protected]

Received date: May 30, 2017; Accepted date: July 01, 2017; Published date: July 03, 2017

Citation: Mani I, Kavita V (2017) Toll-Like Receptor 11: Role in Post-Transplantation Renal Infections . Single Cell Biol 6:164. doi:10.4172/2168-9431.1000164

Copyright: © 2017, Mani I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Uropathogenic microorganisms interact with the intestinal tract mucosa, which activate immune cell responses through the Toll-like receptors (TLRs). TLRs are single, membrane-spanning, non-catalytic proteins and it has significant role in the innate immune system. Recent studies have demonstrated that TLRs expressed in sentinel cells such as dendritic and macrophages cells that recognize structurally conserved molecules derived from microorganisms. Interestingly, the massive infection of the kidney observed in the TLR11 knockout mice, which indicate the hypothesis that TLR11 provides a barrier that prevents uropathogenic bacteria from infecting specifically the post-transplantation kidneys.

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