Topical Anti-Inflammatory Gels of Naproxen Entrapped in Eudragit Based Microsponge Delivery System
Rajurkar VG*, Tambe AB and Deshmukh VK
Quality Assurance Department, MES`s College of Pharmacy, Affiliated To Savitribai Phule Pune University, Maharashtra, India
- *Corresponding Author :
- Rajurkar VG
Quality Assurance Department
MES`s College of Pharmacy, Sonai-414105
Taluka-Newasa, District-Ahmednagar, Maharashtra, India
E-mail: [email protected]
Received April 25, 2015; Accepted May 12, 2015; Published May 19, 2015
Citation: Rajurkar VG, Tambe AB, Deshmukh VK (2015) Topical Anti-Inflammatory Gels of Naproxen Entrapped in Eudragit Based Microsponge Delivery System. J Adv Chem Eng 5:122. doi:10.4172/2090-4568.1000122
Copyright: © 2015 Rajurkar VG et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Naproxen is a medium potency, synthetic, non-steroidal anti-inflammatory drug, indicated for the relief of inflammation. Non-steroidal anti-inflammatory drug`s oral administration contraindicated in patients with peptic ulcer disease, gastro esophageal reflux (GERD), irritable bowel syndrome, or other gastrointestinal disorders. Controlled release of the drug to the skin could reduce the above mentioned side effects related to oral administered drug formulation while reducing percutaneous absorption. Therefore, the aim of present study was to produce naproxen entrapped micro porous micro particles (micro sponges) to control the release of the drug to the skin. Naproxen micro sponge was prepared using quasi emulsion solvent diffusion method. In order to optimize the micro sponge formulation, factors affecting the physical properties of micro sponges were determined. Compatibility of the drug with excipients was studied by FT-IR. Production yield, loading efficiency and surface morphology of micro sponges were performed. It was shown that the drug: polymer ratio and stirring rate influenced the particle size and drug release behaviour of micro sponges. The results showed that, generally an increase in the ratio of the drug: polymer resulted control release rate of naproxen from micro sponges.