alexa Topical Keratolytics for a Case of Porokeratotic Eccrine Ostial and Dermal Duct Nevus
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Case Report

Topical Keratolytics for a Case of Porokeratotic Eccrine Ostial and Dermal Duct Nevus

Ashish Arshanapalli1*, Navid Ezra1, Mouhammad Aouthmany1, Stefanie Hirano-Ali2, Jeffrey B Travers1,3 and Nico Mousdicas1,3

1Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA

2Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

3Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA

*Corresponding Author:
Ashish Arshanapalli
Department of Dermatology, Indiana University
School of Medicine, 1605 N Delaware St Indianapolis
IN 46202, USA
Tel: 219-308-8704
Email: [email protected]

Received date: December 20, 2015 Accepted date: February 09, 2016 Published date: February 12, 2016

Citation:Arshanapalli A, Ezra N, Aouthmany M, Hirano-Ali S, Travers JB, et al. (2016) Topical keratolytics for a Case of Porokeratotic Eccrine Ostial and Dermal Duct Nevus. J Clin Exp Dermatol Res 7:328. doi: 10.4172/2155-9554.1000328

Copyright: © 2016 Arshanapalli A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Porokeratotic Eccrine Ostial and Dermal Duct Nevus (PEODDN) is a rare disorder of keratinization characterized by the presence of cornoid lamellae and association with eccrine sweat ducts. These lesions are usually benign and asymptomatic, so treatment is often for cosmetic purposes. Current therapies for PEODDN are either insufficient or impractical. We present a case of PEODDN treated with topical tretinoin 0.05% cream and 5-fluorouracil 5% cream with the hopes of providing an efficacious, financially relevant, and well-tolerated treatment regime for PEODDN. The combination of topical tretinoin and 5-fluorouracil did not provide substantial improvement in the lesions of a patient treated with this therapy for 6 weeks, and further studies are needed to identify an efficacious treatment for PEODDN that is both well-tolerated and economically feasible for patients with this condition.


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