alexa Towards a Combined Gene and Cell Therapy for Lung Diseases: The Case of Induced Pluripotent Stem Cells | OMICS International
ISSN: 2169-0111

Advancements in Genetic Engineering
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Short Communication

Towards a Combined Gene and Cell Therapy for Lung Diseases: The Case of Induced Pluripotent Stem Cells

Massimo Conese*
Department of Medical and Surgical Sciences, University of Foggia, Italy
Corresponding Author : Prof. Massimo Conese
Department of Medical and Surgical Sciences
University of Foggia
c/o Ospedali Riuniti
Viale L. Pinto 1, Foggia 71122, Italy
Tel: +39-0881-588019
Fax: +39-0881-588037
E-mail: [email protected]
Received October 06, 2012; Accepted October 13, 2012; Published October 15, 2012
Citation: Conese M (2012) Towards a Combined Gene and Cell Therapy for Lung Diseases: The Case of Induced Pluripotent Stem Cells. Adv Genet Eng. 1:103. doi: 10.4172/2169-0111.1000103
Copyright: © 2012 Conese M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Respiratory diseases represent the major cause of morbidity and mortality worldwide, and for them a definitive cure is not included in the pharmacopeia. For example, despite improvements in mechanical
ventilation, acute lung injury and its severe form, acute respiratory distress syndrome, are the leading cause of death in critical care, with mortality rates of 40 to 60%. In the field of chronic lung diseases, treatment with antibiotics and other medicals has prolonged the life span of individuals with cystic fibrosis, the most lethal diseases of the Caucasian population with autosomal recessive inheritance, but this is still limited to 40 years. There is urgent and desperate need of novel effective therapies for these patients.

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