Towards a Universal Influenza Virus Vaccine Eliciting Broadly Neutralising Haemagglutinin Antibodies
Cassandra M Berry*
Murdoch University, Perth, Western Australia, Australia
- *Corresponding Author:
- Berry CM
School of Veterinary and Life Sciences
Murdoch University, Perth, 6150, Western Australia, Australia
E-mail: [email protected]
Received date: November 09, 2015; Accepted date: December 17, 2015; Published date: December 22, 2015
Citation: Cassandra M Berry (2015) Towards a Universal Influenza Virus Vaccine Eliciting Broadly Neutralising Haemagglutinin Antibodies. J Vaccines Vaccin 6:303. doi: 10.4172/2157-7560.1000303
Copyright: © 2015 Berry CM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The surface haemagglutinin (HA) glycoprotein is the immunogenic target for most of the influenza virus immune responses and consists of a globular head and a stalk domain. Recent advances have been made towards the design of a universal influenza virus vaccine to protect against different virus strains based on conserved domains of the HA molecule eliciting broadly neutralising antibodies (bnAb). Development of a universal vaccine for influenza that induces long-lived cross-protective immunity would displace the need for annual seasonal vaccination; prediction of circulating strains and vaccine reformulation. Intense research efforts have been focused on enhancing the potency and breadth of vaccine-induced bnAbs. However, knowledge of how such bnAbs are generated and their mechanisms of action are scarce. Experimental 2-step vaccination approaches using prime-boost regimes stimulate the production of bnAbs but they are usually limited in potency and breadth. Adjuvant enhanced vaccination strategies to elicit potent bnAb and improved B cell memory responses will have an immense impact in global health care and pre-pandemic preparation.