Toxicity Effects of Hair Dye Application on Liver Function in Experimental Animals
- *Corresponding Author:
- Dr. Ehab Ibrahim Salih El-Amin
PhD, Albaha University
Faculty of Applied Medical Sciences
Head of Community Health Department
Kingdom of Saudi Arabia
E-mail: [email protected]
Received Date: June 19, 2014; Accepted Date: August 27, 2014; Published Date: August 29, 2014
Citation: Salih El-Amin E, AL Rahim GahElnabi MA, Mohammed Ahmed WA, Gasim Ahmed R, Eltahir Khalid K (2014) Toxicity Effects of Hair Dye Application on Liver Function in Experimental Animals. J Clin Toxicol 4:210. doi: 10.4172/2161-0495.1000210
Copyright: © 2014 Salih El-Amin EI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: This study was conducted to assess the hair dye toxicity by using hair dye among experimental rats in order to verify the biochemical and haematological abnormalities and liver dysfunction. Methods: Albino Wistar Rats were obtained from the Faculty of Pharmacy, University of Khartoum– Sudan. The rats were divided into two batches on the basis of using the commercial hair dye as oral or subcutaneous administration respectively; each batch has four groups (control and three test groups) each comprising six rats. Batch-1 (group-2, 3, and 4 orally administered with 10, 20, and 30mg/kg body weight of the commercial hair dye, respectively); and Batch-2 (group-2, 3, and 4 subcutaneously administered with 10, 20, and 30 mg/kg body weight of the commercial hair dye, respectively). Results: The clinical features were shown in all rats batches, administered orally or subcutaneously with the commercial hair dye. These clinical features rates from slight weakness in group 2 to head, neck, and pharyngeal oedema in group-3 up to severe weakness in hinds and fore limbs with election of hair, tremors, shivering of the whole body and respiratory distress, severe convulsions, and respiratory difficulty prior to death in group-4. The Biochemical parameters showed significant (P<0.05) increase in the activities of the liver enzymes concomitant with the increase of the commercial hair dye dosage in the two batches, and decrease in the total plasma protein levels, albumin, and cholesterol with the increase of commercial hair dye dosage in the two batches. Hematological parameters showed a significant (p value <0.05) decrease in complete blood count (associated with significant decreases in neutrophils and significant increases of lymphocytes) concomitant with the increasing of commercial hair dye concentration. Conclusion: The study highlighted the major toxicity of commercial hair dye and its association with liver dysfunction.