alexa Toxicity Evaluation of Anisomeles indica Kuntze Leaf Fl
ISSN: 2472-0992

Journal of Pharmacognosy & Natural Products
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Research Article

Toxicity Evaluation of Anisomeles indica Kuntze Leaf Flavonoid Fraction

Giridhara Basappa1, Vadlapudi Kumar1*, Sarojini BK2, Poornima DV1, Hari Gajula1, Torankumar Sannabommaji1 and Rajashekar J1

1Department of Biochemistry, Davangere University, Shivagangothri, Davangere, Karnataka, India

2Department of Biochemistry, Mangalore University, Mangalagangothri, Mangalore, Karnataka, India

*Corresponding Author:
Vadlapudi Kumar
Department of Biochemistry
Davangere University, Shivagangothri
Davangere-577002, Karnataka, India
Tel: +91-8192-208135
Fax: +91-8192-208008
E-mail: [email protected]

Received date: August 01, 2016; Accepted date: August 25, 2016; Published date: August 30,2016

Citation: Basappa G, Kumar V, Sarojini BK, Poornima DV, Gajula H, et al. (2016) Toxicity Evaluation of Anisomeles indica Kuntze Leaf Flavonoid Fraction. J Pharmacogn Nat Prod 2:122. doi: 10.4172/2472-0992.1000122

Copyright: © 2016 Basappa G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Anisomeles indica (L.) Kuntze belongs to Lamiaceae, is used against inflammation and gastric dysfunctions. Tilldate there are no reports on toxicological evaluation of A. indica leaf flavonoids. In the present study, in vivo and in vitro toxicity evaluation of A. indica leaf flavonoid fraction was carried out to assess its safety. Acute toxicity results in mice suggest that, LFF is non-toxic, as the treated animals survived beyond 14-day observation period and with no mortality and toxic signs or symptoms. Subacute oral toxicity study was carried out for 28 days in Swiss albino mice both sexes. Data revealed no statistically significant dose-related effects on food consumption, body weight gain, clinical signs in LFF treated animals. Urine analysis, hematological parameters, serum biochemical examination and histopathology revealed no adverse effects even at 1000 mg/kg body weight/day. In vitro chromosome aberration assay in human lymphocytes revealed no clastogenic effect at 24 h and 48 h LFF treatments. Cytotoxicity results against human cancer cell lines KB, HepG2, HT-29 and HEK-293 suggests, LFF is cytotoxic to four human cancer cell lines with IC50 values 36.57, 40.0, 48.6, 68.58 μg/mL respectively. In conclusion A. indica LFF appears to be safe for oral administration in humans, may be used in traditional medicine.


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