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ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
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Research Article

Toxicity Patterns and Outcomes in Acute Acetaminophen Ingestions

Ahmed Refat Ragab1*, Maha Khalid Al-Mazroua2 and Mona Ahmed Al-Harony1

1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Egypt

2Clinical Pharmacology Expert and Head of Dammam Regional Poison Control Center- Eastern Region – KSA

*Corresponding Author:
Ahmed Refat Ragab
Department of Forensic Medicine and Clinical Toxicology
Faculty of Medicine, Mansoura University, Egypt
E-mail: [email protected]

Received date: February 12, 2013; Accepted date: March 28, 2013; Published date: March 30, 2013

Citation: Ragab AR, Al-Mazroua MK, Al-Harony MA (2013) Toxicity Patterns and Outcomes in Acute Acetaminophen Ingestions. J Drug Metab Toxicol 4:147. doi: 10.4172/2157-7609.1000147

Copyright: © 2013 Ragab AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: Core idea of this research is to comprehend acute acetaminophen toxicities, towards the determination of N-Acetyl Cysteine, relevant time of onset added by protocol therapy. It also looks into determined outcomes.
Subjects and methods: In current research followed retrospective plan of study with a level of eligibility of 307 patients (among whom 200 are males and 107 are females). These patients were from all the age groups and were suffering from acute acetaminophen toxicities as noted within October 2010 to the month of September 2012. These people also have ingestion acetaminophen through intentional/unintentional aspects, and the level of serum acetaminophen under detectable level.
Results: Poisoned acetaminophen offers determined percentage as per ER visits of 307 poisoning case within 1884 (that is 16.2%). Just 6.2% of entire acetaminophen toxicities offered possible/probable hepatic toxicities added by NAC as prescribed with nearly noted equal distribution made through intentional as well as unintentional poisoning mode (52.7% or 47.3%).
Conclusions: There is complete recovery without any mortality record being featured in current research attributing towards very low chronic alcoholism instances as in relevant case studies.

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