alexa Toxicoderma Secondary to 5-Fluorouracil: Differential Diagnosis of Paraneoplastic Pemphigus | OMICS International | Abstract
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Case Report

Toxicoderma Secondary to 5-Fluorouracil: Differential Diagnosis of Paraneoplastic Pemphigus

Olga Martínez Sáez*, Eva Hermosa Zarza, Alfredo Carrato Mena and Reyes Ferreiro Monteagudo

Hospital Universitario Ramon y Cajal, Spain

*Corresponding Author:
Olga Martínez Sáez
Hospital Universitario Ramon y Cajal, Spain
Tel: 34 665029736
E-mail: [email protected]

Received date: April 22, 2016; Accepted date: May 16, 2017; Published date: May 19, 2017

Citation: Sáez OM, Zarza EH, Mena AC, Monteagudo RF (2017) Toxicoderma Secondary to 5-Fluorouracil: Differential Diagnosis of Paraneoplastic Pemphigus. J Clin Exp Dermatol Res 8:396. doi: 10.4172/2155-9554.1000396

Copyright: © 2017 Martínez Sáez O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We present the case of a patient undergoing chemotherapy with 5-Fluorouracil (5-FU), irinotecan and cetuximab, who presented polymorphous skin lesions with oral and genital mucosal involvement. The differential diagnosis included paraneoplastic pemphigus, a severe autoimmune disease associated with neoplasms. The histology can be variable with acantholysis or lichenoid dermatitis. The presence of circulating antibodies supports the diagnosis. In our case, the anatomopathological and immunological findings and the clinical improvement after the suspension of 5-FU confirmed that it was toxicoderma secondary to the latter.

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