Toxicological Properties of Potassium Bromate
Andrzej Starek* and Beata Starek-Świechowicz
Department of Biochemical Toxicology, Chair of Toxicology, Medical College, Jagiellonian Uniwersity, Kraków, Poland
- Corresponding Author:
- Andrzej Starek
Department of Biochemical Toxicology
Chair of Toxicology, Medical College
Jagiellonian Uniwersity, Kraków, Poland
Tel: +48 12 422 10 33
E-mail: [email protected]
Received Date: May 30, 2016; Accepted Date: July 12, 2016; Published Date: July 15, 2016
Citation: Starek, Starek-Swiechowicz (2016) Toxicological Properties of Potassium Bromate. J Pharma Reports 1:122.
Copyright: © 2016 Starek A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Potassium bromate (KBrO3), used in both the food and cosmetics industry, and a drinking water disinfection byproduct, is a nephrotoxic chemical and rodent carcinogen. As KBrO3 is primarily an oxidizing compound, reactive oxygen and other species generated from bromate have been held responsible for the genotoxic, carcinogenic and toxic effects. Bromate induces primary DNA oxidative damage, mutations, and DNA-strand breakage, structural chromosomal aberration types of chromatid breaks and exchanges. KBrO3 induces of micronuclei in different cells in vivo. Bromate is clastogenic agent. Bromate administered in the drinking water was tumorogenic in the rat kidney, thyroid, and mesothelium and was a renal carcinogen in the male mouse. The incidence of mesotheliomas on the tunica vaginalis testis in rats was a dose-dependent manner. It was shown that KBrO3 is an effective promoter of kidney neoplasia induced by N-ethyl-N-hydroxyethylnitrosamine. There are a lot naturally occurring compounds which may be used as effective chemopreventive agents against KBrO3-mediated renal and other organ oxidative stress, toxicity and tumor promotion response.