alexa Toxicological Properties of Potassium Bromate

Journal of Pharmacological Reports
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Toxicological Properties of Potassium Bromate

Andrzej Starek* and Beata Starek-Świechowicz

Department of Biochemical Toxicology, Chair of Toxicology, Medical College, Jagiellonian Uniwersity, Kraków, Poland

Corresponding Author:
Andrzej Starek
Department of Biochemical Toxicology
Chair of Toxicology, Medical College
Jagiellonian Uniwersity, Kraków, Poland
Tel: +48 12 422 10 33
E-mail: [email protected]

Received Date: May 30, 2016; Accepted Date: July 12, 2016; Published Date: July 15, 2016

Citation: Starek, Starek-Swiechowicz (2016) Toxicological Properties of Potassium Bromate. J Pharma Reports 1:122.

Copyright: © 2016 Starek A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Potassium bromate (KBrO3), used in both the food and cosmetics industry, and a drinking water disinfection byproduct, is a nephrotoxic chemical and rodent carcinogen. As KBrO3 is primarily an oxidizing compound, reactive oxygen and other species generated from bromate have been held responsible for the genotoxic, carcinogenic and toxic effects. Bromate induces primary DNA oxidative damage, mutations, and DNA-strand breakage, structural chromosomal aberration types of chromatid breaks and exchanges. KBrO3 induces of micronuclei in different cells in vivo. Bromate is clastogenic agent. Bromate administered in the drinking water was tumorogenic in the rat kidney, thyroid, and mesothelium and was a renal carcinogen in the male mouse. The incidence of mesotheliomas on the tunica vaginalis testis in rats was a dose-dependent manner. It was shown that KBrO3 is an effective promoter of kidney neoplasia induced by N-ethyl-N-hydroxyethylnitrosamine. There are a lot naturally occurring compounds which may be used as effective chemopreventive agents against KBrO3-mediated renal and other organ oxidative stress, toxicity and tumor promotion response.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version