alexa Toxicological Studies of the Ayurvedic Medicine âÂ
ISSN: 0974-8369

Biology and Medicine
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Research Article

Toxicological Studies of the Ayurvedic Medicine “Naradiya Laksmivilasa Rasa” Used in Sinusitis

Shemonty Hasan, Md. Mamun Sikder*, Massnoon Ali, Mustari Hossain, Tasniya Nahiyan Zulfiquar, Ferdousi Akter, Nilay Saha and Choudhuri MSK

Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh

*Corresponding Author:
Sikder MM
Department of Pharmacy, Jahangirnagar University
Savar, Dhaka 1342, Bangladesh
E-mail: [email protected]

Received Date: Aug 23, 2016; Accepted Date: Oct 13, 2016; Published Date: Nov 2, 2016

Citation: Hasan S, Sikder MM, Ali M, Hossain M, Zulfiquar TN, et al. (2016) Toxicological Studies of an Ayurvedic Medicine “Naradiya Laksmivilasa Rasa” Used in Sinusitis. Biol Med (Aligarh) 8: 359. doi:10.4172/0974-8369.1000359

Copyright: © 2016 Hasan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In this study, the toxicological effects along with possible side effects of the classical Ayurvedic formulation Naradiya Laksmivilasa Rasa (NMB), which is used as a traditional medicine in the treatment of sinusitis in the rural population, were evaluated. During this study, various experiments on body growth rate, organ-body weight ratio, and tissue hydration indices were performed to evaluate its efficacy and toxicity. To find out the toxicological characteristics of NMB, it was administered chronically to male Sprague-Dawley rats at a dose of 100 mg/kg. After 32 days of chronic administration of the NMB preparation, the following toxicological changes were noted. Throughout the experimental period, the NMBtreated animals showed negligible [1.04% loss (p 5 0.914) to 3.18% gain (p 5 0.753)] changes in body weight and no statistically significant increase or decrease was noted. The study involving comparison of the relative weight of the major organs of the rats revealed some significant results. There was a statistically highly significant increase in the relative percentage weight of the male rat kidney, along with an increase in the absolute weight of the male rat spleen and an increase in the relative percentage weight of the male rat spleen. In the tissue hydration index experiment, there was a statistically significant increase in the water content of the male rat liver. As NMB increases abnormally, the weight of several organs increases in the body of treated rats, so it should not be administered chronically at a higher dose.

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