Trans Fatty Acids and Atherosclerosis-effects on Inflammation and Endothelial FunctionZapolska DD*, Bryk D and Olejarz W
Department of Biochemistry and Clinical Chemistry, the Warsaw Medical University, Banacha 1 Street, 02-097 Warsaw, Poland
- *Corresponding Author:
- Zapolska DD
Department of Biochemistry and Clinical Chemistry
Medical University of Warsaw, Banacha 1 Street
02-097 Warsaw, Poland
E-mail: [email protected]
Received date: October 02, 2015; Accepted date: November 05, 2015; Published date: November 09, 2015
Citation: Zapolska DD, Bryk D, Olejarz W (2015) Trans Fatty Acids and Atherosclerosis-effects on Inflammation and Endothelial Function. J Nutr Food Sci 5:426. doi: 10.4172/2155-9600.1000426
Copyright: © 2015 Zapolska DD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The current diet and lifestyle are commonly known contributing factors of atherosclerosis, which is the underlying disorder in patients with cardiovascular disease. An identification of any kinds of foods that may exert the cardioprotective or cardiotoxic influence and deeper understanding their molecular mechanisms of action has become an object of interest due to their importance. Through largely epidemiological evidence, trans fatty acids (TFAs) intake has been associated with a variety of the cardiovascular complications, including atherosclerosis. The excessive intake of TFAs has detrimental effect on lipid profile. However, the association between the consumption of TFA and the risk of cardiovascular disease are much greater, than predicted by the effect on serum lipids alone, suggesting that the TFAs intake may also affect the other, non-lipid risk factor. Evidences from many studies indicate, that TFA induce the inflammatory response and endothelial dysfunction. In the following review we present a current knowledge concerning the chemistry of TFAs, their dietary source, their association with cardiovascular disease and the possible mechanisms explaining their effect on atherosclerosis.