alexa Transcriptional Activity of Vitamin D Receptor Gene (VD
ISSN: 2329-8936

Transcriptomics: Open Access
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Transcriptional Activity of Vitamin D Receptor Gene (VDR) and Transforming Growth Factor Beta (TGF-Β) Signaling Differentiate Juvenile and Adolescent Idiopathic Scoliosis

Roman Nowak1, 2*
1Department of Orthopaedics, School of Medicine, Medical University of Silesia, Poland
2Department of Molecular Biology, Medical University of Silesia, Poland
Corresponding Author : Roman Nowak
Department of Orthopaedics
School of Medicine, Medical University of Silesia, Poland
Tel: +48 32 252 17 39
E-mail: [email protected]
Received October 06, 2015; Accepted November 09, 2015; Published November 12, 2015
Citation:Nowak R (2015) Transcriptional Activity of Vitamin D Receptor Gene (VDR) and Transforming Growth Factor Beta (TGF-Β) Signaling Differentiate Juvenile and Adolescent Idiopathic Scoliosis. Transcriptomics 3:118. doi:10.4172/2329-8936.1000118
Copyright: © 2015 Nowak R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Idiopathic scoliosis (IS) is the most common spinal deformity in humans. The exact causes of this condition are unknown but the genetic background seems undisputable. Genetic background doesn’t preclude that IS could be a systemic molecular disorder reflected by local processes affecting musculoskeletal structures of the spine during periods of intensive growth. The age of scoliosis onset is one of the most important factors determining the natural history and the risk of progression. Most of the idiopathic curves are diagnosed in juvenile (Juvenile Idiopathic Scoliosis -JIS) or adolescent period (Adolescent Idiopathic Scoliosis - AIS).

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