alexa
Reach Us +1-504-608-2390
Transdermal Application of Steroid to Cervical Trachea for the Cough in Patients with Bronchial Asthma and Cough Variant Asthma-A Pilot Study | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Transdermal Application of Steroid to Cervical Trachea for the Cough in Patients with Bronchial Asthma and Cough Variant Asthma-A Pilot Study

Mitsuhiro Kamimura1*, Atsuto Mouri1, Kazuo Takayama1, Tomonori Mizutani1, Yoichiro Hamamoto1, Motoyasu Iikura1, Kaneyuki Furihata1, Hiroshi Ishii2 and Kenji Sugibayashi2

1Department of Pulmonology, National Hospital Organization Disaster Medical Center, Japan

2Faculty of Pharmaceutical Sciences, Josai University, Japan

*Corresponding Author:
Mitsuhiro Kamimura
Department of Pulmonology
National Hospital Organization Disaster Medical Center
Midori-machi 3256, Tachikawa-shi
Tokyo 190-0014, Japan
Tel: 042-526-5511
Fax: 042-526-5535
E-mail: [email protected]

Received date: August 01, 2013; Accepted date: October 11, 2013; Published date: October 16, 2013

Citation: Kamimura M, Mouri A, Takayama K, Mizutani T, Hamamoto Y, et al. (2013) Transdermal Application of Steroid to Cervical Trachea for the Cough in Patients with Bronchial Asthma and Cough Variant Asthma-A Pilot Study. J Allergy Ther 4:152. doi: 10.4172/2155-6121.1000152

Copyright: © 2013 Kamimura M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The delivery of steroid to asthmatic patients has been limited to inhalation therapy or systemic therapy. The objective of this study was to evaluate the efficacy of transcutaneous application of steroid over the cervical trachea to asthmatic patients as an alternative route of drug delivery.

Methods: Five patients with bronchial asthma (BA), 10 patients with cough-variant asthma (CVA) and 13 patients with cough predominant asthma (CPA) whose symptoms were not adequately controlled despite their current therapy were enrolled in the study. Steroid ointment of mometasone furoate or betamethasone valerate, in the amount of 1/2 fingertip unit once or twice a day for up to 3 months, to the skin over the cervical trachea, was added to the current therapy. Diphenhydramine ointment was also tried by 14 of the study participants.

Results: Out of 28 patients receiving the steroid treatment, cough was reduced in 11 patients (39.3%). Cough disappeared completely in 3 cases, improved in 7 cases, and reduced temporarily but worsened again during the course in 1 case. Out of 14 patients receiving diphenhydramine treatment, cough was reduced in 5 patients (35.7%).

Conclusions: The existence of responders to topical steroid ointment therapy to the cervical trachea strongly suggests that the trachea is also involved as an airway inflammation site. Though less effective compared to inhaled corticosteroid therapy, the transdermal administration could be regarded as the third route of steroid therapy for asthmatic cough.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version