alexa Transdifferentiation during Heart Regeneration
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Review Article

Transdifferentiation during Heart Regeneration

Xianmei Meng1,2*, Ali Nsair1,2*

1Cardiovascular Research Laboratories, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

2The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

*Corresponding Author:
Xianmei Meng
Cardiovascular Research Laboratories
Department of Medicine and The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Tel: 9093620623
E-mail: [email protected]
*Corresponding Author:
Ali Nsair
Cardiovascular Research Laboratories
Department of Medicine and The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Tel: 310-825-5635
E-mail: [email protected]

Received date: March 12, 2014; Accepted date: April 02, 2014; Published date: April 04, 2014

Citation: Meng X, Nsair A (2014) Transdifferentiation during Heart Regeneration. J Stem Cell Res Ther 4:188. doi: 10.4172/2157-7633.1000188

Copyright: © 2014 Meng X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Heart disease is the leading cause of mortality worldwide. Transdifferentiation, also called direct reprogramming, is a process where a mature somatic cell transforms into another distinct cell type. Rapidly accumulating studies have suggested that transdifferentiation of mature somatic cells into cardiomyocytes and other cell types has provided tremendous hope for the treatment of heart disease. Here I summarize the recent advances, specifically regarding the strategies used for transdifferentiation of cardiac cells during heart regeneration.

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