alexa Transforming Growth Factor and Pre-Eclampsia: Perspecti
ISSN: 2471-9552

Immunotherapy: Open Access
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Transforming Growth Factor and Pre-Eclampsia: Perspectives for Novel Therapeutic Modalities

Parveen Jahan1*, Goske Deepthi2, Kamakshi Chaithri Ponnaluri2 and Komaravalli Prasanna Latha2

1Department of Zoology, MANUU, Hyderabad-32, Telangana State, India

2Department of Genetics, Osmania University, Hyderabad-07, Telangana State, India

*Corresponding Author:
Parveen Jahan
Department of Zoology, MANUU
Hyderabad-32, Telangana State, India
Tel: 9885186923
E-mail: [email protected]

Received date: February 17, 2016 Accepted date: March 07, 2016 Published date: March 10, 2016

Citation: Jahan P, Deepthi G, Ponnaluri KC, Latha KP (2016) Transforming Growth Factor - B1 and Pre-Eclampsia: Perspectives for Novel Therapeutic Modalities. Immunother Open Acc 2:113. doi:10.4172/2471-9552.1000113

Copyright: © 2016 Jahan P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Breakdown in the immunoregulatory mechanism as well as dysregulated angiogenesis are critical contributors to the obstetric disorder, Pre-eclampsia [PE]. The pleiotropic cytokine, Transforming Growth Factor-β1 [TGF-β1], with its immunosuppressive and angiogenic functions appears to be a promising candidate for prospective therapies in PE, as gleaned from a survey of candidate gene association and biochemical investigations. The current article endows with a background and gives inkling for the plausible therapeutic strategies for PE employing TGF-β1, given the veracity that proper curative procedures are not yet existent for this disorder.


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