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ISSN: 2168-9849

Cloning & Transgenesis
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Review Article

Transgenic Zebrafish Models for Understanding Retinitis Pigmentosa

Raghupathy RK, Patnaik SR and Shu X*
Department of Life Sciences, Glasgow Caledonian University, Glasgow, UK
Corresponding Author : Xinhua Shu
Department of Life Sciences
Glasgow Caledonian University
Cowcaddens Road, Glasgow, UK
E-mail: [email protected]
Received July 24, 2013; Accepted August 05, 2013; Published August 07, 2013
Citation: Raghupathy RK, Patnaik SR, Shu X (2013) Transgenic Zebrafish Models for Understanding Retinitis Pigmentosa. Clon Transgen 2:110. doi:10.4172/2168-9849.1000110
Copyright: © 2013 Raghupathy RK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Retinitis pigmentosa (RP) is a heterogeneous genetic retinal disorder, characterized by impaired dark adaption and progressive loss of photoreceptor cells. More than 46 genes have been identified to be responsible for RP, but the functional roles of RP-causing mutants are largely unknown. Due to the similarities of anatomy, physiology and functional signal pathways to human retina, the zebrafish has become a valuable model to study human retinal diseases. With the aid of improved techniques in transgenesis, the use of the zebrafish model has been accelerated, especially in the field of retinal degeneration. In this brief review, we will present an overview of the transgenic approaches in zebrafish and the utility of transgenic zebrafish for assessing the pathogenicity of RP-causing alleles.

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