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ISSN: 2168-9547

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Commentary

Transglycosidases and Fungal Cell Wall β-(1,3)-Glucan Branching

Vishukumar Aimanianda*

 

Unité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France

*Corresponding Author:
Vishukumar Aimanianda
Unité des Aspergillus, Institut Pasteur
25 rue du Docteur Roux, Paris 75015, France
Tel: 33145688225
E-mail: [email protected]

Received date: July 20, 2017; Accepted date: August 03, 2017; Published date: August 10, 2017

Citation: Aimanianda V (2017) Transglycosidases and Fungal Cell Wall β-(1,3)-Glucan Branching. Mol Biol 6:194. doi:10.4172/2168-9547.1000194

Copyright: © 2017 Aimanianda V. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Fungal cells are endowed with a cell wall that plays a crucial role in the fungal life, by providing mechanical strength and protecting fungal cells from their environment. Chemically, this fungal cell wall consists of different polysaccharides, contributing to 80-95% of the cell wall dry mass. The core cell wall structure is made up of β-(1,6)-branched β-(1,3)- glucan linked to chitin, and is common to all fungal species. Branching leads to β-(1,3)-glucan ramificating, facilitating its cross-linking with chitin as well as other cell wall components resulting in the construction of a functional fungal cell wall. Recently, using Saccharomyces cerevsiae as the model, we showed that the dual activity associated with CAZy family GH72 transglycosidases (https://www.cazy.org/) belonging to the GAS-family, are capable of elongating as well as branching β-(1,3)-glucan, an essential phenomenon during cell wall biogenesis and remodeling. Not only GAS-proteins, but also GEL-family protein from Aspergillus fumigatus (a pathogenic fungus) showed β-(1,3)- glucan elongating-branching activity. Interestingly, this dual activity was shown by only those GH72 family members containing a Carbohydrate Binding Motif-43 (CBM), suggesting that branching activity is universal in the fungal kingdom. Disruption of β-(1,3)-glucan branching resulted either in a sick-phenotype or led to inviability, suggesting that β-(1,3)-glucan branching is an essential phenomenon during fungal cell wall biogenesis. In this commentary, future perspectives on our findings are presented.

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