alexa Translational Development of Biocompatible X-Ray Visible Microspheres for Use in Transcatheter Embolization Procedures | OMICS International | Abstract
ISSN: 2169-0022

Journal of Material Sciences & Engineering
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Research Article

Translational Development of Biocompatible X-Ray Visible Microspheres for Use in Transcatheter Embolization Procedures

Benzina A1, Aldenhoff YB2, Heijboer R3 and Koole LH2,4*

1Faculty of Health, Medicine and Life Sciences, Maastricht University, UniSingel 50, 6229 ER Maastricht, The Netherlands

2Interface Biomaterials BV, B. Lemmensstraat 364, 6163 JT Geleen, The Netherlands

3Zuyderland Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands

4Department of Biomedical Engineering, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Malaysia

*Corresponding Author:
Koole LH
Interface Biomaterials BV
B. Lemmensstraat 364, 6163
JT Geleen, The Netherlands
Tel: 31464757989
E-mail: [email protected]

Received Date: February 02, 2016; Accepted Date: March 04, 2016; Published Date: March 14, 2016

Citation: Benzina A, Aldenhoff YB, Heijboer R, Koole LH (2016) Translational Development of Biocompatible X-Ray Visible Microspheres for Use in Transcatheter Embolization Procedures. J Material Sci Eng 5:238. doi:10.4172/2169-0022.1000238

Copyright: © 2016 Benzina A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Embolization is a minimally invasive treatment that specifically blocks the arterial blood flow into a target blood vessel bed, which is usually a benign or malignant tumor. The aim of the procedure is to shrink the tumor and/or to retard its growth. Embolization the injection of embolic particles via a catheter tube, of which the tip has been navigated carefully (under X-ray guidance) into an arterial branch that exclusively feeds the tumor, and no surrounding healthy tissues. Most of the clinical experience with embolization relates to treatment of leiomyomata (benign tumors growing in the wall of the uterus). There is solid evidence that catheter-based embolization of leiomyomata provides a fully acceptable therapeutic alternative for much more demanding surgical procedures (i.e., hysterectomy and myomectomy). Embolization offers much faster recovery, possible options to become pregnant, and considerable cost saving. There are several commercial brands of embolization agents, suitable to treat leiomyomata. We hypothesized, some years ago, that these products are suboptimal, and that embolization of leiomyomata may be improved further through better engineering of the embolic particles. We developed injectable radiopaque polymer microspheres, which can be monitored during and after the embolization procedure. The embolic microbeads are X-ray traceable, and this has been achieved without compromising other essential properties, such as structural stability and excellent biocompatibility. Herein, we describe new the features of the new embolic microspheres, as observed in preclinical experiments and in the first clinical cases. It is mentioned briefly that this work became an example of successful translation: it has led to a new medical device (Class-IIB) that is now CE-certified and commercially available throughout Europe.

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