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Translational Science of Psychosis in Parkinsonand#8217;s Disease | OMICS International | Abstract
ISSN: 2572-0791

Clinical Depression
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Review Article

Translational Science of Psychosis in Parkinson’s Disease

Syeda Arshiya Farheen1, Pooja Shah2, Manpreet Gill3, Sumayya Ayaz4, Satneet Singh5, Archana Adikey6, Venkatesh Sreeram7, Rizwan Ahmed8 , Mariyah Hussain9 and Saeed Ahmed10*

1Kakatiya Medical college, India;

2S.S.R Medical College, Mauritius;

3Stanford University School of Medicine, USA;

4Dhaka Medical College, Bangladesh;

5Tver State Medical Academy, Russia;

6King County Hospital Center, USA;

7Yale University Diagnostic Radiology, USA;

8Liaquat Medical and Dentistry College, Pakistan;

9Foundation university Medical College, Pakistan;

10Nassau University Medical Center, USA.

*Corresponding Author:
Ahmed S
Nassau University Medical Center, USA
Tel: 93298445854
E-mail: [email protected]

Received Date: Septemeber 24, 2015 Accepted Date: Septemeber 27, 2015 Published Date: Novomber 15, 2015

Citation: Farheen SA, Shah P, Gill M, Ayaz S, Singh S, et al. (2015) Translational Science of Psychosis in Parkinson’s Disease. Clin Depress 1:102. doi:10.4172/2572-0791.1000102

Copyright: © 2015 Farheen SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopamine in the substantia nigra. It is predominantly a motor disorder but has shown to present with psychosis in few cases. Psychotic symptoms result from chronic treatment with few anti- Parkinson’s medications, ranging from depression, delusions to visual hallucinations, eventually progressing to auditory hallucinations in a few cases. Presence of psychotic symptoms with loss of insight is indicative of late stage of Parkinson’s disease and has poor prognosis. Accurate diagnosis of symptoms can be difficult due to significant overlapping clinical presentations which can be an admixture of underlying disease, exacerbation of pre-existing psychiatric illness or iatrogenic. The article below portrays the complex interplay between Parkinson’s disease psychosis, medications and underlying disease process which heralds early identification of the symptoms using diagnostic tools and imaging techniques to improve the health of individuals and the community by “translating” findings into diagnostic tools and medicines. It also highlights the dire need to develop neuroprotective drugs as a mode of primary prevention of psychosis. We cannot underemphasize the need to educate the patient and caregiver to seek medical attention at earliest for prompt identification and application of disease modifying therapies to reduce disability and morbidity associated with it and limit nursing home placements