alexa Treatment Associated Interstitial Pulmonary Toxicity of Temozolomide Plus Bevacizumab for Locally Advanced Solitary Fibrous Tumor
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
Open Access

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Case Report

Treatment Associated Interstitial Pulmonary Toxicity of Temozolomide Plus Bevacizumab for Locally Advanced Solitary Fibrous Tumor

Heissner K1,*, Horger M2, Spengler W1, Steger V3, Kanz L1, Biro D4and Kopp HG1

1Department of Medical Oncology, Hematology, Immunology, Rheumatology and Pulmology, Medical Center II, South West German Comprehensive Cancer Center, University Hospital of Tuebingen, Germany

2Department of Radiology, Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Germany

3Department of Thoracic and Cardiovascular Surgery, University Hospital of Tuebingen, Germany

4Department of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital of Tuebingen, Germany

*Corresponding Author:
Klaus Heissner
Center for Soft Tissue Sarcoma
GIST and Bone Tumors, Southwest German Tumor
Center Comprehensive Cancer Center (CCC)
Otfried-Müller-Str. 10, 72076 Tübingen, Germany
Tel: +49 7071 29 82714
Fax: +49 7071 29 4399
E-mail: [email protected]

Received date: December 17, 2015; Accepted date: January 13, 2016; Published date:/strong> January 18, 2016

Citation:Heissner K, Horger M, Spengler W, Steger V, Kanz L, et al. (2016) Treatment Associated Interstitial Pulmonary Toxicity of Temozolomide Plus Bevacizumab for Locally Advanced Solitary Fibrous Tumor. J Pulm Respir Med 6:314. doi:10.4172/2161-105X.1000314

Copyright: © 2016 Heissner K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Solitary Fibrous Tumors (SFT), previously termed haemangiopericytoma, are rare soft tissue sarcomas (STS). They usually grow slowly and show indolent behaviour in terms of malignancy. Surgery in localized disease is the only curative approach. While metastatic disease occurs rarely, locally advanced SFT often require systemic treatment. Systemic treatment for inoperable SFT is not standardized, and chemotherapy displays only modest activity. Temozolomide plus bevacizumab is a relatively active treatment option. Its advantages are prolonged tumor stabilisation combined with an overall low toxicity profile. We report the first case of treatment related interstitial pulmonary toxicity caused by temozolomide in combination with bevacizumab during treatment of SFT.


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