alexa Treatment of Hypercholesterolemia
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

Treatment of Hypercholesterolemia

Wilbert S Aronow*
Department of Medicine, Divisions of Cardiology, Geriatrics, and Pulmonary Medicine/Critical Care, New York Medical College, Valhalla, NY, USA
Corresponding Author : Wilbert S. Aronow
Cardiology Division, New York Medical College
Macy Pavilion, Room 138, Valhalla, NY 10595, USA
Tel: (914) 493-5311
Fax: (914) 235-6274
E-mail: [email protected]
Received April 21, 2013; Accepted May 10, 2013; Published June 06, 2013
Citation: Aronow WS (2013) Treatment of Hypercholesterolemia. J Clin Exp Cardiolog S1:006. doi:10.4172/2155-9880.S1-006
Copyright: © 2013 Aronow WS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Numerous randomized, double blind, placebo-controlled studies and observational studies have shown that statins reduce mortality and major cardiovascular events in high-risk patients with hypercholesterolemia. The Heart Protection Study showed that statins reduced mortality and major cardiovascular events in high-risk patients regardless of the initial level of serum lipids, age, or gender. The updated National Cholesterol Education program III guidelines state that in very high-risk persons, a serum low-density lipoprotein (LDL) cholesterol level of <70 mg/L is a reasonable clinical strategy. For moderately high-risk persons ( 2 or more risk factors and a 10-year risk for coronary artery disease of 10% to 20%), the serum LDL cholesterol should be reduced to <100 mg/dL. When LDL cholesterol-lowering drug therapy is used to treat high-risk persons or moderately high-risk persons, the serum LDL cholesterol should be reduced at least 30% to 40%. The serum LDL cholesterol should be decreased to less than 160 mg/dl in persons at low risk for cardiovascular disease. Addition of other lipid-lowering drugs to statin therapy has not been found to further reduce cardiovascular events and mortality.

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