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Treatment with Autologous Bone Marrow Mononuclear Cells in Patients with Non Reconstructable Critical Lower Limb Ischaemia | OMICS International | Abstract
ISSN: 2161-0991

Journal of Transplantation Technologies & Research
Open Access

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Research Article

Treatment with Autologous Bone Marrow Mononuclear Cells in Patients with Non Reconstructable Critical Lower Limb Ischaemia

Alaa Ismail*, Hussein E, Sabbour A, Fawzy W, Anas Meshaal and Mounir R

Vascular Unit of General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

*Corresponding Author:
Alaa Ismail, MD, FACS
Vascular Unit of General Surgery Department
Faculty of Medicine
Ain Shams University, Cairo, Egypt
E-mail: [email protected]

Received Date: January 23, 2012; Accepted Date: March 08, 2012; Published Date: March 13, 2012

Citation: Ismail A, Hussein E, Sabbour A, Fawzy W, Meshaal A, et al. (2012) Treatment with Autologous Bone Marrow Mononuclear Cells in Patients with Non Reconstructable Critical Lower Limb Ischaemia. J Transplant Technol Res 2: 110. doi: 10.4172/2161-0991.1000110

Copyright: © 2012 Ismail A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and Aims: Treatment with autologous, bone marrow mononuclear stem cells has shown effects in patients with chronic limb ischaemia. The aim of the study was to test the potential effect of stem cell treatment in a strict defined group of patients with non reconstructable critical limb ischaemia (CLI).

Material: Twenty patients with non recontructable CLI of the lower extremities, who received medical treatment in the form of prostavasine.

Methods: Bone marrow cells were harvested from the patient’s iliac crest and, after separation, injected into the calf muscles of the affected leg. Outcome was evaluated by digital subtraction angiography (DSA), visual analogue scale (VAO) one patient was amputated two months after cell injection. Two patients reported relief of pain after four months.

Conclusion: This method seems to be a safe option for treating patients with non reconstructable CLI.

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