T-Regulatory Cells: The Recently Recognized Players of ImmunomodulationVanikar AV1* and Trivedi HL2
1Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology and Department of Stem Cell Biology and Regenerative Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)-Dr.H.L. Trivedi Institute of Transplantation Sciences (ITS), India
2Department of Nephrology and Transplantation Medicine and Department of Stem Cell Biology and Regenerative Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)-Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), India
- *Corresponding Author:
- Vanikar AV
Department of Pathology, Laboratory Medicine
Transfusion Services and Immunohematology and Dept. of Stem Cell Biology and Regenerative Medicine
G. R. Doshi and K. M. Mehta Institute Of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation, [ITS], Civil Hospital Campus, Asarwa, Ahmedabad- 380016, Gujarat, India
Tel: 0091792268 7153
Received date: September 07, 2014; Accepted date: October 24, 2014; Published date: November 10, 2014
Citation: Vanikar AV, Trivedi HL (2014) T-Regulatory Cells: The Recently Recognized Players of Immunomodulation. J Stem Cell Res Ther 4:241. doi:10.4172/2157-7633.1000241
Copyright: © 2014 Vanikar AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recently a subpopulation of T cells known as regulatory T cells (Tregs) have been identified to play important role of immunomodulation in autoimmune diseases, cancer and also in transplantation immunobiology. Tregs have been identified as biomarkers for graft function status. We have generated Tregs in vitro and also used them in kidney transplantation. We have found their efficacy in safe minimization of immunosuppression in kidney transplantation. Tregs are likely to form an integral part of cell therapy which will completely change the field of clinical transplantation. However there is a wide chasm between basic cell biologists and immunobiologists (who understand the significance of Tregs) and clinicians (who do not appreciate the bedside role of Tregs). This review article discusses the genesis of Tregs, their identification markers and their diagnostic and therapeutic role in transplantation immunobiology.