alexa Triple Effect of Nonsense-Mediated mRNA Decay Inhibitio
ISSN: 2168-9431

Single Cell Biology
Open Access

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Perspective Article

Triple Effect of Nonsense-Mediated mRNA Decay Inhibition as a Therapeutic Approach for Cancer

Fabrice Lejeune1,2,3*

1University of Lille, UMR8161-M3T-Mechanisms of Tumorigenesis and Target Therapies, F-59000 Lille, France

2CNRS, UMR 8161, F-59000 Lille, France

3Institut Pasteur de Lille, F-59000 Lille, France

Corresponding Author:
Fabrice Lejeune
University of Lille, UMR8161-M3TMechanisms
of Tumorigenesis and Target Therapies, F-59000 Lille, France
Tel: +3332043434
E-mail: [email protected]

Received date: March 25, 2016; Accepted date: April 27, 2016; Published date: April 29, 2016

Citation: Lejeune F (2016) Triple Effect of Nonsense-Mediated mRNA Decay Inhibition as a Therapeutic Approach for Cancer. Single Cell Biol 5:136. doi:10.4172/2168-9431.1000136

Copyright: © 2016 Lejeune F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Cancer is a complex pathology involving different genes and cellular pathways. A combination of treatments with different targets is thus required to eliminate cancer cells. This review deals with a new potential therapeutic approach: inhibiting a single RNA degradation pathway so as to inhibit tumorigenesis by acting on different cellular processes and on the expression of various genes. Also discussed is the re-expression of various genes: tumor suppressor genes harboring a nonsense mutation, NMD-silenced oncogenes, and genes inducing a specific anticancer immune response. Lastly, putative limitations of cancer treatment by NMD inhibition are addressed.


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