TSH - Clinical Aspects of its Use in Determining Thyroid Disease in the Elderly How does it Impact the Practice of Medicine in Aging?
|Mackenzie Deary1, Timothy Buckey1 and Offie P. Soldin1,2*|
|1Georgetown University Medical Center, 3800 Reservoir Road NW, Washington DC 20057, USA|
|2Departments of Oncology, Medicine, Obstetrics and Gynecology, Pharmacology and Physiology, Georgetown University Medical Center, Washington DC|
|*Corresponding Author :||Dr. Offie P. Soldin
Department of Oncology, Lombardi Comprehensive Cancer Center
LL, S-166, Georgetown University Medical Center
3800 Reservoir Road NW, Washington DC 20057, USA
E-mail: [email protected]
|Received September 21, 2012; Accepted October 27, 2012; Published October 29, 2012|
|Citation: Deary M, Buckey T, Soldin OP (2012) TSH -Clinical Aspects of its Use in Determining Thyroid Disease in the Elderly How does it Impact the Practice of Medicine in Aging? Adv Pharmacoepidem Drug Safety 1:119. doi:10.4172/2167-1052.1000119|
|Copyright: © 2012 Deary M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
The last four decades have seen enormous growth in the efficacy of serum thyroid stimulating hormone (thyrotropin, TSH) assay methodology, establishing TSH as the hallmark of thyroid testing. At the center of the considerations is the strong positive correlation between serum thyrotropin and free thyroxine concentrations. While it is widely accepted that elevated serum TSH concentrations are consistent with thyroid dysfunction, a vast multitude of additional factors must be considered before an accurate clinical diagnosis can be made followed by an appropriate treatment. Epidemiological studies have demonstrated slightly elevated serum TSH concentrations among the elderly population. There is, however, a debate whether these elevated TSH levels reflect an increased prevalence of hypothyroidism among the elderly or a normal aspect of healthy aging. A comprehensive analysis of the many variables associated with this debate and TSH measurement as a diagnostic tool in aging, should provide insight into the clinical efforts to diagnose and treat thyroid disease, particularly in the elderly population.