alexa Tumor Budding as a Useful Prognostic Indicator in Early Oral Squamous Cell Carcinoma | OMICS International| Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Review Article   
  • J Cancer Sci Ther/Vol.10.6 162(2018),
  • DOI: 10.4172/1948-5956.1000536

Tumor Budding as a Useful Prognostic Indicator in Early Oral Squamous Cell Carcinoma

Tadaaki Kirita*, Nobuhiro Yamakawa, Nobuhiro Ueda and Takahiro Yagyuu
Department of Oral and Maxillofacial Surgery, Nara Medical University, Schijo-cho, Nara-Kashihara, Japan
*Corresponding Author : Tadaaki Kirita, Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Schijo-cho, Nara-Kashihara 634-8521, Japan, Tel: +81-744-22-3051, Fax: +81-744-29-8875, Email: [email protected]

Received Date: May 10, 2018 / Accepted Date: Jun 20, 2018 / Published Date: Jun 22, 2018

Abstract

Tumor budding, defined as the presence of single cancer cells or small clusters of fewer than five cells at the tumor invasive front, has been reported to be an independent prognostic factor for several cancers together with margin status, depth of invasion, lymph vascular invasion, and lymph node metastasis. Distant metastasis and poor prognosis were significantly more common in the higher budding group. In this short review, we focused on the studies related to tumor budding in several cancers including oral squamous cell carcinoma(OSCC) and showed the association among the intensity of tumor budding, risk of lymph node metastasis, and poor prognosis in OSCC is strongly supported by many studies. Moreover, arguments for the assessment of tumor budding, scoring system, stains to mark budding, specimens, and the association with epithelial mesenchymal transition (EMT) are also discussed.

Keywords: Tumor budding; Oral cavity; Squamous cell carcinoma; Prognostic indicator

Citation: Kirita T, Yamakawa N, Ueda N, Yagyuu T (2018) Tumor Budding as a Useful Prognostic Indicator in Early Oral Squamous Cell Carcinoma. J Cancer Sci Ther 10: 162-167. Doi: 10.4172/1948-5956.1000536

Copyright: © 2018 Kirita T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Relevant Topics
Recommended Conferences
Article Usage
  • Total views: 2034
  • [From(publication date): 0-2018 - Dec 15, 2019]
  • Breakdown by view type
  • HTML page views: 1943
  • PDF downloads: 91
Top